David PS
Member
Trigonelline is an alkaloid is a zwitterion formed by the methylation of the nitrogen atom of niacin (vitamin B3). It is a product of niacin metabolism that is excreted in urine of mammals. Trigonelline is lower in muscle with the age-related progressive loss of muscle mass and strength (saropenia). Surprising to me, drinking coffee, (especially from light roasted beans) can raise the level of trigonelline in muscle and is it appears to have a much longer life in vivo than some of the other NAD+ precusors. It is laid out in the video below. For convenience, I have included some images from the presentation.
View: https://www.youtube.com/watch?v=5S8fkfTPWC0
NAD+ levels are low in Sarcopenic muscle.
Fig. 6c - Muscle NAD+ levels positively correlate to ALM-index, grip strength, gait speed, and mitochondrial complex I activity.
In more recent work reported in the video,
It appears the trigonelline is much more stable than NR and NMR in the human body.
This article was mentioned in the video -
View: https://www.youtube.com/watch?v=5S8fkfTPWC0
NAD+ levels are low in Sarcopenic muscle.
Fig. 6c - Muscle NAD+ levels positively correlate to ALM-index, grip strength, gait speed, and mitochondrial complex I activity.
In more recent work reported in the video,
It appears the trigonelline is much more stable than NR and NMR in the human body.
This article was mentioned in the video -