Xemnoraq
Member
- Joined
- Oct 3, 2016
- Messages
- 271
- Age
- 28
So i’ve always been interested in the research and possible beneficial side to tobacco for medicinal or pro-metabolic purposes similar to caffeine, however, as many people are aware there are plenty of downsides to smoking.
From my own personal experience, i really enjoy tobacco alot, however i noticed ever since using it, i started getting horrible migranes which i had never had before, and my veins towards my head and forehead would buldge up and not circulate fully to the top, i would get huge brain congestion as Ray had called it before from what felt like serotonin syndrome or serotonin overload,
I also noticed when using or coming off of tobacco, i would have extreme serotonin symptoms,
For example i found myself extremely irritable, impatient, disconnected, and also just extremely nervous and defensive, i started developing patterns of horrible social anxiety.
And so based on the physical symptoms of bad circulation to my head and mood based symptoms it got me thinking about serotonin and tobacco.
I know so many other people who can smoke ridiculous amounts and never get such severe issues, my theory is they may have a much higher ability to produce progesterone, and progesterone raises MAO and lowers serotonin, and ultimately detoxes or staves off alot of bad stuff.
So this study examines the MAO-A levels in the brains of smokers and found they had signifigantly lower levels of MAO compared to non-smokers,
A deficiency of MAO has been characterized before as the warrior gene in people with very high serotonin,
Brain monoamine oxidase A inhibition in cigarette smokers
“Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%). The mean λk3values for the whole brain were 0.18 ± 0.04 and 0.13 ± 0.03 ccbrain (mlplasma)−1 min−1 for nonsmokers and smokers, respectively; P < 0.0003). Tranylcypromine treatment reduced λk3 by an average of 58% for the different brain regions. Our results show that tobacco smoke exposure is associated with a marked reduction in brain MAO A, and this reduction is about half of that produced by a brief treatment with tranylcypromine.”
“MAO exists in two subtypes (MAO A and B) that are different gene products (8, 9). In the brain, MAO A oxidizes serotonin and norepinephrine and is found primarily in catecholaminergic neurons”
The unfortunate thing about the conductors of this study, is they still see serotonin as a good thing, and believe that a deficiency of MAO protects against depression thats where they mentioned SSRI’s being effective anti-depressants through this mechanism of MAO inhibition i believe, however we know all too well the horrible effects of SSRI’s.
My question now to everyone on here, DOES tobacco, technically act like an SSRI in some regards? Through the inhibition of MAO-A and B, resulting in increased levels of serotonin and adrenaline? Could tobacco cause serotonin syndrome like SRRI’s could?
These are things i definetly feel and experience with tobacco, and while it does have some great positive effects, whenever i quit i feel like i get serotonin syndrome from it, and progesterone seems to be very theraputic.
I’m not also trying to say that because this is my own personal experience it must be fact but it does line up with everything the study has to say about MAO and serotonin (despite their altered views on the subject)
I feel as though again the people who have a high resistance to these negatives who can smoke excessively, i would have to guess they are people who already have good ability to produce the protective hormones like progesterone which promote MAO etc.
If anybody has any knowledge on this specific area of area regarding tobacco and serotonin itd be nice to hear other peoples thoughts.
If anyone also has some interesting positives to share on tobacco that’d be interesting too, i know there’s plenty of studies showing it actually improves progesterone and DHEA synthesis, so not everthing is clear cut or black and white.
From my own personal experience, i really enjoy tobacco alot, however i noticed ever since using it, i started getting horrible migranes which i had never had before, and my veins towards my head and forehead would buldge up and not circulate fully to the top, i would get huge brain congestion as Ray had called it before from what felt like serotonin syndrome or serotonin overload,
I also noticed when using or coming off of tobacco, i would have extreme serotonin symptoms,
For example i found myself extremely irritable, impatient, disconnected, and also just extremely nervous and defensive, i started developing patterns of horrible social anxiety.
And so based on the physical symptoms of bad circulation to my head and mood based symptoms it got me thinking about serotonin and tobacco.
I know so many other people who can smoke ridiculous amounts and never get such severe issues, my theory is they may have a much higher ability to produce progesterone, and progesterone raises MAO and lowers serotonin, and ultimately detoxes or staves off alot of bad stuff.
So this study examines the MAO-A levels in the brains of smokers and found they had signifigantly lower levels of MAO compared to non-smokers,
A deficiency of MAO has been characterized before as the warrior gene in people with very high serotonin,
Brain monoamine oxidase A inhibition in cigarette smokers
“Smokers had significantly lower brain MAO A than nonsmokers in all brain regions examined (average reduction, 28%). The mean λk3values for the whole brain were 0.18 ± 0.04 and 0.13 ± 0.03 ccbrain (mlplasma)−1 min−1 for nonsmokers and smokers, respectively; P < 0.0003). Tranylcypromine treatment reduced λk3 by an average of 58% for the different brain regions. Our results show that tobacco smoke exposure is associated with a marked reduction in brain MAO A, and this reduction is about half of that produced by a brief treatment with tranylcypromine.”
“MAO exists in two subtypes (MAO A and B) that are different gene products (8, 9). In the brain, MAO A oxidizes serotonin and norepinephrine and is found primarily in catecholaminergic neurons”
The unfortunate thing about the conductors of this study, is they still see serotonin as a good thing, and believe that a deficiency of MAO protects against depression thats where they mentioned SSRI’s being effective anti-depressants through this mechanism of MAO inhibition i believe, however we know all too well the horrible effects of SSRI’s.
My question now to everyone on here, DOES tobacco, technically act like an SSRI in some regards? Through the inhibition of MAO-A and B, resulting in increased levels of serotonin and adrenaline? Could tobacco cause serotonin syndrome like SRRI’s could?
These are things i definetly feel and experience with tobacco, and while it does have some great positive effects, whenever i quit i feel like i get serotonin syndrome from it, and progesterone seems to be very theraputic.
I’m not also trying to say that because this is my own personal experience it must be fact but it does line up with everything the study has to say about MAO and serotonin (despite their altered views on the subject)
I feel as though again the people who have a high resistance to these negatives who can smoke excessively, i would have to guess they are people who already have good ability to produce the protective hormones like progesterone which promote MAO etc.
If anybody has any knowledge on this specific area of area regarding tobacco and serotonin itd be nice to hear other peoples thoughts.
If anyone also has some interesting positives to share on tobacco that’d be interesting too, i know there’s plenty of studies showing it actually improves progesterone and DHEA synthesis, so not everthing is clear cut or black and white.