aguilaroja
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- Joined
- Jul 24, 2013
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This study was done with tissue culture of breast cancer cells. It used the Hcl form of thiamine, which as @haidut is the form often used in studies showing beneficial thiamine effects and is widely available. The separate thread is started for emphasis, and is a continuation of @haidut’s thread:
Thiamine Acts Similarly To DCA And May Be Helpful In Cancer
The Effects of Thiamine on Breast Cancer Cells
“Thiamine has a distinct advantage over drugs such as dichloroacetate because it is a water-soluble vitamin that is harmless, even in excess. Moreover, we have already shown that administration of thiamine to thiamine-deficient patients can quickly cause a whole-body shift from aerobic glycolysis toward aerobic metabolism”
“Thiamine had a number of effects in MCF7; it (1) reduced extracellular lactate levels in growth media, (2) increased cellular pyruvate dehydrogenase (PDH) activities and the baseline and maximum cellular oxygen consumption rates, and (3) decreased non-glycolytic acidification, glycolysis, and glycolytic capacity.”
“Conclusions: The treatment of MCF7 breast cancer cells with 1 μg/mL and 2 μg/mL of thiamine for 24 h significantly reduced their proliferation. This reduction is associated with a reduction in glycolysis and activation of the PDH complex in breast cancer cells.”
Thiamine Acts Similarly To DCA And May Be Helpful In Cancer
The Effects of Thiamine on Breast Cancer Cells
“Thiamine has a distinct advantage over drugs such as dichloroacetate because it is a water-soluble vitamin that is harmless, even in excess. Moreover, we have already shown that administration of thiamine to thiamine-deficient patients can quickly cause a whole-body shift from aerobic glycolysis toward aerobic metabolism”
“Thiamine had a number of effects in MCF7; it (1) reduced extracellular lactate levels in growth media, (2) increased cellular pyruvate dehydrogenase (PDH) activities and the baseline and maximum cellular oxygen consumption rates, and (3) decreased non-glycolytic acidification, glycolysis, and glycolytic capacity.”
“Conclusions: The treatment of MCF7 breast cancer cells with 1 μg/mL and 2 μg/mL of thiamine for 24 h significantly reduced their proliferation. This reduction is associated with a reduction in glycolysis and activation of the PDH complex in breast cancer cells.”