Mito
Member
- Joined
- Dec 10, 2016
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- 2,554
“To our knowledge, this is the first study to show that NAD+ levels steeply declines with age in human plasma. On the contrary to previous reports, this study provides strong evidence for the availability of the extracellular NAD+ and its related metabolites in plasma. This is important since NAD+ is vital to numerous cellular processes including oxidative phosphorylation and energy production, immune function (through CD38 activity), DNA repair (through PARP activity), nuclear signaling and protein function (through sirtuin activity), and telomere maintenance (through Tankyrase1 activity). Critical depletion of NAD+ results in cell death through reduced ATP production and activation of apoptosis.62Reliable measurements of plasma NAD+ metabolites should greatly aid in the effective upregulation of intracellular NAD+ using NAD+ and related precursors for the purpose of maintaining critical cellular processes and thereby ameliorating some age-related cellular degeneration and resulting pathologies.”
https://www.liebertpub.com/doi/10.1089/rej.2018.2077
https://www.liebertpub.com/doi/10.1089/rej.2018.2077