InChristAlone
Member
Welp if you don't think it applies to this discussion because you aren't using it and that some cases might be a drug interaction then you probably won't believe this paper either about men developing breasts after isotretinoin: https://sci-hub.hkvisa.net/10.3109/15569527.2012.705406Here's a review of the reports of depression and suicide that come from isotretinoin-
Isotretinoin, depression and suicide: a review of the evidence
There is currently considerable controversy regarding a proposed causal relationship between the use of isotretinoin and depression and suicide. A search was made of the MEDLINE, EMBASE and PsychINFO databases using the search terms ‘isotretinoin’, ...www.ncbi.nlm.nih.gov
That's not many total cases (although the suicides are tragic), and the article goes onto state that over 8 Million patients had used it by 1998.
However.... was it isotretonin that caused these?
So, this could have been a serious reaction between drugs, not the direct action of isotretonin itself. LSD and cannabis are well known to cause mood and behavior changes.
I appreciate your concern, but I think you are overstating risk (especially since I am using retinol, and not isotretonin or tretinoin). Of course, if anyone is considering any course of action, it's always best to do a well informed analysis of potential risks and benefits, ideally with the help of a well trained medical professional.
"There are few studies that showed the effect of isotretinoin on androgen metabolism. In a study after 3 months of treatment with isotretinoin, both testosterone and LH levels were decreased (3). In another study, testosterone and androstenedion are found to be lower after 12 weeks of treatment with isotretinoin."
I mean I could go on and on. I will always advise caution with any retinol/retinoid drug or supplement and even with liver. For every study showing some small benefit there are 10 showing harm. I don't think there are any other supplements or drugs that have such a long history of harm when overdoing it. Accutane may change a teenager's life for the better if they have their severe acne cured, but they are routinely monitored and told not to get pregnant because it is toxic, it is working as a chemical agent. I classify that similar to using chemo for cancer. Sure it may result in remission, but at what long term cost?