Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
I've been wondering why I haven't come across any studies on the effectiveness of saturated fatty acids against SARS-cov-2/ the spike protein, since medium and long chain fatty acids like MCT, lauric acid and policosanol have been shown to have anti-viral activity.
Here ,this study showed an anti viral effect of metadichol (specifically against coronaviruses) ,which is a
"nano-emulsion of a type of lipid molecule called policosanol,...".
It also shows high effectiveness at inhibiting
TMPRSS2, which enables spike protein activation and viral entry.
So in other words policosanol is a spike protein antagonist.
On top of that it inhibits SARS-cov-2 replication directly in vitro.
Of course we dont know if regular policosanol does the same, but it has been shown to have anti viral activity before (Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho) so I'd be surprised if it doesn't have a similar action.
So in light of that evidence ,it seems we found another weapon against coronaviruses and its spike protein, which people are exposed to through infection , shedding or vaccination.
"Naturally derived substances, such as long-chain saturated lipid alcohols, reduce the infectivity of various types of viruses, including coronaviruses such as SARS-COV-2, by modifying lipid-dependent attachment to human host cells. SARS-COV-2 uses the receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming.
Metadichol®, a nano lipid formulation of long-chain alcohols, has been shown to inhibit TMPRSS2 (EC50 96 ng/ml). Compared to the inhibitor camostat mesylate (EC50 26000 ng/ml), it is 270 times more potent. Additionally, Metadichol® is also a weak inhibitor of ACE2 at 31 µg/ml. Further a live virus assay in Caco2 cells, Metadichol® inhibited SARS-CoV-2 replication with an EC90 of 0.16 µg/ml."
Here ,this study showed an anti viral effect of metadichol (specifically against coronaviruses) ,which is a
"nano-emulsion of a type of lipid molecule called policosanol,...".
It also shows high effectiveness at inhibiting
TMPRSS2, which enables spike protein activation and viral entry.
So in other words policosanol is a spike protein antagonist.
On top of that it inhibits SARS-cov-2 replication directly in vitro.
Of course we dont know if regular policosanol does the same, but it has been shown to have anti viral activity before (Policosanol Is Antiviral And A Potent Inducer Of Anti-aging Gene Klotho) so I'd be surprised if it doesn't have a similar action.
So in light of that evidence ,it seems we found another weapon against coronaviruses and its spike protein, which people are exposed to through infection , shedding or vaccination.
"Naturally derived substances, such as long-chain saturated lipid alcohols, reduce the infectivity of various types of viruses, including coronaviruses such as SARS-COV-2, by modifying lipid-dependent attachment to human host cells. SARS-COV-2 uses the receptor ACE2 for entry and the serine protease TMPRSS2 for S protein priming.
Metadichol®, a nano lipid formulation of long-chain alcohols, has been shown to inhibit TMPRSS2 (EC50 96 ng/ml). Compared to the inhibitor camostat mesylate (EC50 26000 ng/ml), it is 270 times more potent. Additionally, Metadichol® is also a weak inhibitor of ACE2 at 31 µg/ml. Further a live virus assay in Caco2 cells, Metadichol® inhibited SARS-CoV-2 replication with an EC90 of 0.16 µg/ml."
Metadichol®, A Novel Nano Lipid Formulation that Inhibits SARS-CoV-2 and a Multitude of Pathological Viruses in Vitro
New pathogenic virus outbreaks, occurring with increasing regularity, are leading us to explore novel approaches, which will reduce the reliance on time-consumi
papers.ssrn.com