Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
- 5,669
Piracetam is a great substance and has so many uses ,yet its still not fully understood how it works .
Let us collect some studies to paint a better picture on what it does.
@Hans @Razvan @Charger @Ismail
Here are some studies from my notes: :
Here's a very interesting study concerning piracetam for cancer treatment.
"Tumor remissions were observed in several male animals. "
"All animals treated in this manner for 7 months remained tumor-free."
([Antineoplastic activity of drugs affecting the central nervous system against chemically induced tumors in the rat (author's transl)] - PubMed)
Piracetam and phenotropil increase the dopamine and noradrenaline content in the brain [1, 4].
7-fold administrations of phenotropil induced an increase indensities of NMDA receptors in the hippocampus, nicotinic receptors in the cortex, and D3-dopamine receptors in the striatum [3]
Piracetam is an agonist of
glutamate quisqualate autoreceptors [7]
The affinity of phenylpiracetam to the nicotinitic acetylcholine (nACh) receptor, but not the glutamate NMDA subtype, was demonstrated in ligand-binding experiments in vitro. However, injection of this drug (100 mg/kg, intraperitoneally) to rats increases the numbers of both nACh and NMDA receptors, but decreases serotonin and dopamine
receptors in the brain tissue.[40]"
(Piracetam and Piracetam-Like Drugs - Drugs)
It lowers glutamate .
(Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum - PubMed)
different effects depending on the dosage . With low/medium doses beeing more nootropic and high doses more anxiolytic.
([The nootropic and anxiolytic properties of different doses of piracetam] - PubMed)
Long term safe. This study administered up to 20g per day for 18 months .
(Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy - PubMed)
In this study they took 8g/d for 1 year and the drug was well tolerated .
(Long‐term and high‐dose piracetam treatment of Alzheimer's disease)
Piracetam, an analog of GABA, improves
learning, increases resistance to toxins or oxygen
deprivation, and increases bilateral symmetry of
function in the cerebral hemispheres (Giurgea,
1973)."
-RP
(A Biophysical Approach To Altered Consciousness, Ray Peat)
It increases BDNF.
([Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy] - PubMed)
Let us collect some studies to paint a better picture on what it does.
@Hans @Razvan @Charger @Ismail
Here are some studies from my notes: :
Here's a very interesting study concerning piracetam for cancer treatment.
"Tumor remissions were observed in several male animals. "
"All animals treated in this manner for 7 months remained tumor-free."
([Antineoplastic activity of drugs affecting the central nervous system against chemically induced tumors in the rat (author's transl)] - PubMed)
Piracetam and phenotropil increase the dopamine and noradrenaline content in the brain [1, 4].
7-fold administrations of phenotropil induced an increase indensities of NMDA receptors in the hippocampus, nicotinic receptors in the cortex, and D3-dopamine receptors in the striatum [3]
Piracetam is an agonist of
glutamate quisqualate autoreceptors [7]
The affinity of phenylpiracetam to the nicotinitic acetylcholine (nACh) receptor, but not the glutamate NMDA subtype, was demonstrated in ligand-binding experiments in vitro. However, injection of this drug (100 mg/kg, intraperitoneally) to rats increases the numbers of both nACh and NMDA receptors, but decreases serotonin and dopamine
receptors in the brain tissue.[40]"
(Piracetam and Piracetam-Like Drugs - Drugs)
It lowers glutamate .
(Activation of quisqualate metabotropic receptors reduces glutamate and GABA-mediated synaptic potentials in the rat striatum - PubMed)
different effects depending on the dosage . With low/medium doses beeing more nootropic and high doses more anxiolytic.
([The nootropic and anxiolytic properties of different doses of piracetam] - PubMed)
Long term safe. This study administered up to 20g per day for 18 months .
(Long-term efficacy and safety of piracetam in the treatment of progressive myoclonus epilepsy - PubMed)
In this study they took 8g/d for 1 year and the drug was well tolerated .
(Long‐term and high‐dose piracetam treatment of Alzheimer's disease)
Piracetam, an analog of GABA, improves
learning, increases resistance to toxins or oxygen
deprivation, and increases bilateral symmetry of
function in the cerebral hemispheres (Giurgea,
1973)."
-RP
(A Biophysical Approach To Altered Consciousness, Ray Peat)
It increases BDNF.
([Effects of nootropic drugs on hippocampal and cortical BDNF levels in mice with different exploratory behavior efficacy] - PubMed)