Mauritio
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- Feb 26, 2018
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This study looked at the effect of microdoses (2 μg/mL drinking water) of nicotine on mice.
Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels.
This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in anti-oxidant enzymes, lowering of inflammation and oxidative stress, improvement of cognition and neurogenesis, etc...
Nicotine restores the NAMPT to levels to those of young mice. In some organs even above that.
The interesting thing about nicotine was that higher or lower doses were not as effective or even ineffective.
So there seems to be a sweet spot at a tissue level of about 10ng/ml of nicotine.
In the in-vivo study the oral dose was about 8mcg /day/rat (2mcg/ml drinking water). A mouse weighs about 20g, so 0.4mcg/1g or 400mcg/kg.
Divided by 12 for the usual conversion to humans equals 33,33mcg/kg. Multiplied by 75 for average human weight equals a HED of almost exactly 2.5mg/day.
(I might have screwed up the calculation, so correct me if I'm wrong.)
As it is completely water-soluble, it should be relatively easy to dilute nicotine and take microdoses. Worth a try.
- Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity
Nicotine was able to rescue the rate limiting enzyme for NAD synthesis, NAMPT, and improve NAD levels.
This comes of course with all the goodies of a higher NAD/NADH ration, in this case: increase in anti-oxidant enzymes, lowering of inflammation and oxidative stress, improvement of cognition and neurogenesis, etc...
Nicotine restores the NAMPT to levels to those of young mice. In some organs even above that.
The interesting thing about nicotine was that higher or lower doses were not as effective or even ineffective.
So there seems to be a sweet spot at a tissue level of about 10ng/ml of nicotine.
In the in-vivo study the oral dose was about 8mcg /day/rat (2mcg/ml drinking water). A mouse weighs about 20g, so 0.4mcg/1g or 400mcg/kg.
Divided by 12 for the usual conversion to humans equals 33,33mcg/kg. Multiplied by 75 for average human weight equals a HED of almost exactly 2.5mg/day.
(I might have screwed up the calculation, so correct me if I'm wrong.)
As it is completely water-soluble, it should be relatively easy to dilute nicotine and take microdoses. Worth a try.
- Nicotine rebalances NAD+ homeostasis and improves aging-related symptoms in male mice by enhancing NAMPT activity
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