griesburner
Member
- Joined
- Sep 29, 2017
- Messages
- 142
Hey,
im reading in this forum for years and the information i got is very impressive so far :)
Now i decided to join and register to help getting thinks clearer.
There are so many questions in my mind, often from reading so conflicting studys, especially when it comes to nitric oxide and arginine for example. I know arginine is not very peat approved thats for sure cause as a precurser to nitric oxide it should have very negative side-effects.
As im new to this forum i think im not allowed to post any links here, so i am not able to post any studies i think :/
I know that there are studies that show some side-effects, but the mayority of studies i found to supplementing with l-arginine especially for heart and endothelial health seem very promising.
The coincidence i dont understand is the following:
- most studies show that arginine increases NO - resulting in better blood flow, lower blood pressure etc.
- L-NAME (N(G)-Nitro-L-arginine methyl ester), the substance used in studies to reduce NO - raises hypertension, causes vasoconstriction etc.
I know CO2 should be the primary vasodilator if NO is low, but in animal research if NO is supressed, there seems to be no compensatory mechanism of CO2 short term. Maybe longterm if NO is supressed that will happen? i dont know and i havent found studies to show this.
Im very curious about this question because i have an inflammatory rheumatoid desease, and to keep my arteries etc healthy i want to do the best i can. In theory the best should be to keep nitric oxide low cause its inflammatory. but i even found intervention studies in patients who have rheumatoid arthritis with l-arginine and they got better and it was approved to be safe. that makes my confusion even greater
PS: as a side note. i dont post this to try to convince someone that arginine is good. im just curious why there are so many studies showing the potential benefits
Maybe u guys have a better understanding and can help me :)
im reading in this forum for years and the information i got is very impressive so far :)
Now i decided to join and register to help getting thinks clearer.
There are so many questions in my mind, often from reading so conflicting studys, especially when it comes to nitric oxide and arginine for example. I know arginine is not very peat approved thats for sure cause as a precurser to nitric oxide it should have very negative side-effects.
As im new to this forum i think im not allowed to post any links here, so i am not able to post any studies i think :/
I know that there are studies that show some side-effects, but the mayority of studies i found to supplementing with l-arginine especially for heart and endothelial health seem very promising.
The coincidence i dont understand is the following:
- most studies show that arginine increases NO - resulting in better blood flow, lower blood pressure etc.
- L-NAME (N(G)-Nitro-L-arginine methyl ester), the substance used in studies to reduce NO - raises hypertension, causes vasoconstriction etc.
I know CO2 should be the primary vasodilator if NO is low, but in animal research if NO is supressed, there seems to be no compensatory mechanism of CO2 short term. Maybe longterm if NO is supressed that will happen? i dont know and i havent found studies to show this.
Im very curious about this question because i have an inflammatory rheumatoid desease, and to keep my arteries etc healthy i want to do the best i can. In theory the best should be to keep nitric oxide low cause its inflammatory. but i even found intervention studies in patients who have rheumatoid arthritis with l-arginine and they got better and it was approved to be safe. that makes my confusion even greater
PS: as a side note. i dont post this to try to convince someone that arginine is good. im just curious why there are so many studies showing the potential benefits
Maybe u guys have a better understanding and can help me :)