Mr. God of Cars
Member
- Joined
- May 2, 2016
- Messages
- 165
Ray Peat said:
° "Saturated fats activate the pyruvate dehydrogenase enzyme that is essential for the efficient use of glucose, while PUFA block it." [1, 1.5]
° "In the 1940s, Bernardo Houssay found that coconut oil protected animals from poison-induced diabetes, while a lard-based diet failed to protect them. Later, glucose itself was found to protect the pancreatic beta-cells from poisons." [2, 3, 4]
We eat sucrose, part of which is broken down to glucose, which is converted to pyruvate in the glycolysis metabolic pathway. The pyruvate is, then, converted into Acetyl-CoA, which then delivers its acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production, producing CO2, ATP, water, and heat. But B-oxidation of fats is also a source of substrate for the pyruvate production.
"Cancer researchers have become interested in this enzyme system that controls the oxidation of pyruvic acid (and thus sugar) by the mitochondria, since these enzymes are crucially defective in cancer cells (and also in diabetes). The chemical DCA, dichloroacetate, is effective against a variety of cancers, and it acts by reactivating the enzymes that oxidize pyruvic acid." [5]
So, if these enzymes (specifically pyruvate dehydrogenase) is defective in diabetes, then diabetes is not a matter of sugar or fat oxidation problem, but a matter of pyruvate conversion into Acetyl-CoA. Am I right?
° "Saturated fats activate the pyruvate dehydrogenase enzyme that is essential for the efficient use of glucose, while PUFA block it." [1, 1.5]
° "In the 1940s, Bernardo Houssay found that coconut oil protected animals from poison-induced diabetes, while a lard-based diet failed to protect them. Later, glucose itself was found to protect the pancreatic beta-cells from poisons." [2, 3, 4]
We eat sucrose, part of which is broken down to glucose, which is converted to pyruvate in the glycolysis metabolic pathway. The pyruvate is, then, converted into Acetyl-CoA, which then delivers its acetyl group to the citric acid cycle (Krebs cycle) to be oxidized for energy production, producing CO2, ATP, water, and heat. But B-oxidation of fats is also a source of substrate for the pyruvate production.
"Cancer researchers have become interested in this enzyme system that controls the oxidation of pyruvic acid (and thus sugar) by the mitochondria, since these enzymes are crucially defective in cancer cells (and also in diabetes). The chemical DCA, dichloroacetate, is effective against a variety of cancers, and it acts by reactivating the enzymes that oxidize pyruvic acid." [5]
So, if these enzymes (specifically pyruvate dehydrogenase) is defective in diabetes, then diabetes is not a matter of sugar or fat oxidation problem, but a matter of pyruvate conversion into Acetyl-CoA. Am I right?