TreasureVibe
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- Jul 3, 2016
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Because someone mentioned to me on this forum that iron was important for dopamine metabolism, and antipsychotic drugs cause dangerous cardiovascular side effects through its interference with the body's dopamine system, I decided to do a Google search for "antipsychotic drugs iron". I know that the body uses dopamine to control the heart functions, and that antipsychotic drugs use has been associated with an increased risk of heart failure, cardiovascular disease and sudden death in studies.
I came across the following study paper, which suggests that antipsychotic drugs can induce an iron deficiency:
Antipsychotic Drugs Induced Iron Deficiency Anemia in Schizophrenic Patients
Abstract
Published Online: December 2013
Background: Psychiatric manifestations and its association with the antipsychotic drugs induced IDA is still controversial. Iron deficiency is the most evident risk factor for developing neuroleptic-induced extra pyramidal symptoms (EPSs), on the basis of emerging evidences; here we report the iron deficiency anemia observed in the on antipsychotic drug treated schizophrenic patients.
Methods: The hematological and absolute indices, morphological and serum iron indices assessment was focused on 120 Pakistani schizophrenic patients, who were on the chronic treatment of antipsychotic drug particularly haloperidol for more than 12 weeks of clinical practice, and 44 normal controls.
Results: Marked decrease (p<0.0001) was observed in the hematological
indices such as hemoglobin, RBCs count and packed cell volume while
marked but insignificant decrease was observed in the level of mean cell volume (MCV) in the schizophrenic patients. The morphological assessment shows significant alterations on the peripheral blood smear of the schizophrenic patients with hypochromic (>10%) and microcytic cells as compared to normocytic - normochromic controls. The serum ferritin and iron levels in these patients were within the normal range. However, significant (p<0.0001) inverse correlation was observed in the level of serum iron and ferritin with increased TIBC level in the schizophrenic patients as
compared to the normal individuals.
Conclusion: The present study clearly delineates on the basis of sequential analysis, morphological and biochemical assessment that the type of microcytic-hypochromic anemia is iron deficiency anemia. Moreover, the clinical manifestation of iron deficiency anemia are varied and related to its severity and duration.
Full study paper available to download as PDF at: Article Detail - International Journal of Advanced Research
A Google search for "mitral valve iron" shows up multiple studies that show iron deficiency as an independent predictor for mitral valve regurgitation, and that it is common in patients who suffer from valvular heart disease and patients who undergo cardiac valve replacement:
The association of functional mitral regurgitation and anemia in patients with non-ischemic dilated cardiomyopathy. - PubMed - NCBI
[Iron deficiency following implantation of a heart valve prosthesis]. - PubMed - NCBI
[Anemia in patients with artificial heart valves (author's transl)]. - PubMed - NCBI
Traumatic Hemolysis with Iron Deficiency Anemia in Patients with Aortic Valve Lesions | Annals of Internal Medicine | American College of Physicians
Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis
[Investigations of iron and folate levels in serum after implantation of heart valve prostheses (author's transl)]. - PubMed - NCBI
[Haemolysis after heart valve replacement (author's transl)]. - PubMed - NCBI
A Google search for "heart disease iron" comes up with a lot of studies including:
Iron deficiency and heart disease: ironclad evidence? - PubMed - NCBI
Anemia in chronic heart failure: can we treat? What to treat? - PubMed - NCBI
Anemia and iron deficiency in heart failure. - PubMed - NCBI
Low iron levels linked with increased risk of heart disease
[Anaemia in chronic heart failure]. - PubMed - NCBI
[Diagnosis and treatment of anemia in heart failure patients]. - PubMed - NCBI
Recognition and treatment of anemia in the setting of heart failure due to systolic left ventricular dysfunction. - PubMed - NCBI
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.030099#
So all in all, I think antipsychotic drugs can cause iron deficiency anemia, which impairs/decreases dopamine metabolism/production, which in part causes heart disease like heart failure.
I came across the following study paper, which suggests that antipsychotic drugs can induce an iron deficiency:
Antipsychotic Drugs Induced Iron Deficiency Anemia in Schizophrenic Patients
Abstract
Published Online: December 2013
Background: Psychiatric manifestations and its association with the antipsychotic drugs induced IDA is still controversial. Iron deficiency is the most evident risk factor for developing neuroleptic-induced extra pyramidal symptoms (EPSs), on the basis of emerging evidences; here we report the iron deficiency anemia observed in the on antipsychotic drug treated schizophrenic patients.
Methods: The hematological and absolute indices, morphological and serum iron indices assessment was focused on 120 Pakistani schizophrenic patients, who were on the chronic treatment of antipsychotic drug particularly haloperidol for more than 12 weeks of clinical practice, and 44 normal controls.
Results: Marked decrease (p<0.0001) was observed in the hematological
indices such as hemoglobin, RBCs count and packed cell volume while
marked but insignificant decrease was observed in the level of mean cell volume (MCV) in the schizophrenic patients. The morphological assessment shows significant alterations on the peripheral blood smear of the schizophrenic patients with hypochromic (>10%) and microcytic cells as compared to normocytic - normochromic controls. The serum ferritin and iron levels in these patients were within the normal range. However, significant (p<0.0001) inverse correlation was observed in the level of serum iron and ferritin with increased TIBC level in the schizophrenic patients as
compared to the normal individuals.
Conclusion: The present study clearly delineates on the basis of sequential analysis, morphological and biochemical assessment that the type of microcytic-hypochromic anemia is iron deficiency anemia. Moreover, the clinical manifestation of iron deficiency anemia are varied and related to its severity and duration.
Full study paper available to download as PDF at: Article Detail - International Journal of Advanced Research
A Google search for "mitral valve iron" shows up multiple studies that show iron deficiency as an independent predictor for mitral valve regurgitation, and that it is common in patients who suffer from valvular heart disease and patients who undergo cardiac valve replacement:
The association of functional mitral regurgitation and anemia in patients with non-ischemic dilated cardiomyopathy. - PubMed - NCBI
[Iron deficiency following implantation of a heart valve prosthesis]. - PubMed - NCBI
[Anemia in patients with artificial heart valves (author's transl)]. - PubMed - NCBI
Traumatic Hemolysis with Iron Deficiency Anemia in Patients with Aortic Valve Lesions | Annals of Internal Medicine | American College of Physicians
Prevalence and prognostic implication of iron deficiency and anaemia in patients with severe aortic stenosis
[Investigations of iron and folate levels in serum after implantation of heart valve prostheses (author's transl)]. - PubMed - NCBI
[Haemolysis after heart valve replacement (author's transl)]. - PubMed - NCBI
A Google search for "heart disease iron" comes up with a lot of studies including:
Iron deficiency and heart disease: ironclad evidence? - PubMed - NCBI
Anemia in chronic heart failure: can we treat? What to treat? - PubMed - NCBI
Anemia and iron deficiency in heart failure. - PubMed - NCBI
Low iron levels linked with increased risk of heart disease
[Anaemia in chronic heart failure]. - PubMed - NCBI
[Diagnosis and treatment of anemia in heart failure patients]. - PubMed - NCBI
Recognition and treatment of anemia in the setting of heart failure due to systolic left ventricular dysfunction. - PubMed - NCBI
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.118.030099#
So all in all, I think antipsychotic drugs can cause iron deficiency anemia, which impairs/decreases dopamine metabolism/production, which in part causes heart disease like heart failure.
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