Curiousman
Member
- Joined
- Aug 2, 2017
- Messages
- 92
Coffee too !!@Curiousman thanks for that quote
@Terma just found this study which I thought you might find interesting. I noticed the chronic shedding started soon after I started drinking alcohol, but even when I stopped drinking alcohol for several years the shedding didn't stop. Suggesting maybe that alcohol has a lasting effect on DNA and methylation, but in my case clearly can be rectified with Folate in the correct form
https://www.sciencedirect.com/science/article/pii/S0741832905000996
"ethanol impedes the bioavailability of dietary folate and is known to inhibit select folate-dependent biochemical reactions. For example, alcohol ingestion in animals is known to inhibit folate-mediated methionine synthesis and thereby may interrupt critical methylation processes that are mediated by the activated form of methionine that provides substrate for biologic methylation, S-adenosylmethionine. Consistent with this observed inhibition of methionine synthesis is the observation that chronic alcohol ingestion in laboratory animals is known to produce hypomethylation of DNA in the colonic mucosa, a constant feature of early colorectal neoplasia. Inhibition of methionine synthase also creates a “methylfolate trap,” analogous to what occurs in vitamin B12 deficiency. In addition, some evidence indicates that alcohol may redirect the utilization of folate toward serine synthesis and thereby may interfere with a critical function of methylenetetrahydrofolate, thymidine synthesis."