LucH
Member
- Joined
- Jul 17, 2015
- Messages
- 433
Hi,Is there anything that improves transit which I can take with cypro other than cascara (which causes me to develop infections each time I try it) and magnesium (which doesn’t help my transit time?
What about your MMC.?
Prokinetics and Intestinal Motility
Dr D’ORO (Swiss Dr)
Mechanism of prokinetics Prokinetics are products, either natural or medicinal, that stimulate and coordinate intestinal motility, making it more effective. They act on various receptors in the intestine, thus allowing varied mechanisms of action. Some prokinetics inhibit dopamine which acts as an inhibitor on the digestive system. (…) Other substances also act on acetylcholine receptors which is a stimulating neurotransmitter of the intestine, other substances act on antagonistic (5-HT3) or agonist (5HT4) serotonin receptors. Etc. Thanks to these combinations of action, prokinetics have the capacity to amplify and coordinate muscular contractions of the intestine. They can act on different sites of action, both on the upper part of the digestive system such as the stomach or the small intestine and on the colon. Prokinetics can improve gastric emptying by coordinating the closing of the lower esophageal sphincter and the opening of the pyloric sphincter while the stomach contracts. They are known for their ability to stimulate the migrating motor complex (MMC) to clean the small intestine of this waste. Certain prokinetics have the ability to improve intestinal transit and can be used for example during constipation. However, prokinetics should not be confused with laxatives. (…) We will see that there are natural or medicinal prokinetics.
Note: I’ve used Resolror 0.5 gr as prokinetic.
Info on MMC
“The complexity of the relationships between motility, transit and absorption is mainly due to the numerous parameters which characterize an intestinal contraction and to the nature of the intestinal contents.” (1)
1. Role of motility in intestinal transit and absorption
J Fioramonti 1, L Buéno. Presse Med. 1989 Feb 15;18(6):249-54.