Mauritio
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- Joined
- Feb 26, 2018
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This study shows that caprylic acid combined with thymol and or carvacrol is very effective against Candida albicans .
In isolation there was a reduction in candida cells 0,6 log CFU/ml ,but combined the reduction was at least 6,8log CFU/ml.
The MoA is a 2 step process. First caprylic acid destroys the cell membrane and then the anti-fungal (thymol,carvacrol ,etc.) destroys the pathogen .
Given this MoA it should work with every other anti-fungal as well .
Now I don't know if they used thymol or carvacrol or both together ,but they have similar properties, so I dont think it matters too much .
I looked online to find thymol and I only found thymol or thyme oil (of which a third is thymol) as an essential oil .
Now I am not sure if it's safe to consume essential oils. I have found conflicting information on it .
Has anybody any info on that ?
Normally its just thyme oil as the only ingredient in those essential oils, but its very, very concentrated ,so I think that makes it unsafe as you can easily ingest too much or burn your throat if ingested . But if that's the only downside, I'd be willing to try it.
"Whereas the maximum reduction by individual treatments was 0.6 log CFU/ml, CA + CAR/THM (all 1.5 mM) eliminated all pathogens (> 6.8 log reduction) after 1 min at 37°C and after 10 min at 22°C. The flow cytometry results showed that exposure to CA damaged the membranes in 15.7-36.5% of cells and inhibited efflux pumps in 15.4-31.3% of cells. Treatments with CAR/THM slightly affected cell membranes (in 1.8-6.9% of cells) but damaged efflux pumps in 14.4-29.6% of cells. However, the combined treatments clearly disrupted membranes (> 83.1% of cells) and pumps (> 95.0% of cells). The mechanism of this synergism may involve membrane damage by CA, which facilitates the entry of antifungals into the cytoplasm, and the inhibition of efflux pumps by CA, CAR or THM, causing their accumulation within cells and, leading to cell death."
In isolation there was a reduction in candida cells 0,6 log CFU/ml ,but combined the reduction was at least 6,8log CFU/ml.
The MoA is a 2 step process. First caprylic acid destroys the cell membrane and then the anti-fungal (thymol,carvacrol ,etc.) destroys the pathogen .
Given this MoA it should work with every other anti-fungal as well .
Now I don't know if they used thymol or carvacrol or both together ,but they have similar properties, so I dont think it matters too much .
I looked online to find thymol and I only found thymol or thyme oil (of which a third is thymol) as an essential oil .
Now I am not sure if it's safe to consume essential oils. I have found conflicting information on it .
Has anybody any info on that ?
Normally its just thyme oil as the only ingredient in those essential oils, but its very, very concentrated ,so I think that makes it unsafe as you can easily ingest too much or burn your throat if ingested . But if that's the only downside, I'd be willing to try it.
"Whereas the maximum reduction by individual treatments was 0.6 log CFU/ml, CA + CAR/THM (all 1.5 mM) eliminated all pathogens (> 6.8 log reduction) after 1 min at 37°C and after 10 min at 22°C. The flow cytometry results showed that exposure to CA damaged the membranes in 15.7-36.5% of cells and inhibited efflux pumps in 15.4-31.3% of cells. Treatments with CAR/THM slightly affected cell membranes (in 1.8-6.9% of cells) but damaged efflux pumps in 14.4-29.6% of cells. However, the combined treatments clearly disrupted membranes (> 83.1% of cells) and pumps (> 95.0% of cells). The mechanism of this synergism may involve membrane damage by CA, which facilitates the entry of antifungals into the cytoplasm, and the inhibition of efflux pumps by CA, CAR or THM, causing their accumulation within cells and, leading to cell death."
Short-Term Antifungal Treatments of Caprylic Acid with Carvacrol or Thymol Induce Synergistic 6-Log Reduction of Pathogenic Candida albicans by Cell Membrane Disruption and Efflux Pump Inhibition - PubMed
Antifungal composites (CA + CAR/THM) showing synergism (i.e., an additional 6 log reduction) within minutes at room/body temperature can be used to treat candidiasis and improve the microbiological safety of facilities contaminated with fungi as a novel alternative to synthetic antifungals.
pubmed.ncbi.nlm.nih.gov