While searching for the ideal calcium supplement I came across calcium alpha-ketoglutarate which I think has not been discussed on this forum yet and looks highly interesting. There is a study showing that calcium alpha-ketoglutarate extends lifespan and compresses morbidity in aging mice
Calcium alpha-ketoglutarate is also a good phosphate binder and effectively treats secondary hyperparathyroidsm:
Alpha-ketoglutarate also lowers ammonia and has antioxidant functions. For review, see
Furthermore, it seems to have positive effect on the microbiome and to lower intestinal inflammation:
The effects of dietary supplementation with α-ketoglutarate on the intestinal microbiota, metabolic profiles, and ammonia levels in growing pigs - ScienceDirect
Europe PMC
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway
Unfortunately, I couldn't find pure calcium alpha-ketoglutarate as a supplement. If anyone can find it let me know. The only products with calcium alpha-ketoglutarate I could find are the following:
Alpha Ketoglutaric Acid 300 mg - Hypoallergenic from Kirkman
Calcium AKG
https://rejuvant.com/f/Mens-Ingredients.jpg
They all contain problematic fillers.
Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Azar Asadi Shahmirzadi, Daniel Edgar, Chen-Yu Liao, Yueh-Mei Hsu, Mark Lucanic, Arash Asadi Shahmirzadi, Christopher Wiley, Rebeccah Riley, Brian Kaplowitz, Garbo Gan, Chisaka Kuehnemann, Dipa Bhaumik, Judith Campisi, Brian K Kennedy, Gordon J. Lithgow
doi: Alpha-ketoglutarate, an endogenous metabolite, extends lifespan and compresses morbidity in aging mice
Abstract
The decline in early life mortality since the 1950s has resulted in dramatic demographic shift towards aged population. Aging manifests as a decline in health, multiple organ dysfunction and increased vulnerability to diseases, which degrades quality of life. A verity of genetic and pharmacological interventions, mostly from non-vertebrate models, have been identified that can enhance lifespan. Whether these interventions extend healthspan, the disease free and functional period of life, has only sometimes been tested and is often a matter of debate. Human aging indices have been developed to assess elements of functional decline with aging (e.g. sarcopenia, cognitive function). However, corresponding comprehensive indices in mice are seldom applied to aging studies. To probe the relationship between healthspan and lifespan extension in mammals, we performed a series of longitudinal, clinically-relevant healthspan measurements. Metabolism and aging are tightly connected and specific perturbations of nutrient-sensing pathways can enhance longevity in laboratory animals. Here we show that alpha-ketoglutarate (delivered in the form of a Calcium salt, CaAKG), a key metabolite in tricarboxylic (TCA) cycle that is reported to extend lifespan in worms, can significantly extend lifespan and healthspan in mice. AKG is involved in various fundamental processes including collagen synthesis and epigenetic changes. Due to its broad roles in multiple biological processes, AKG has been a subject of interest for researchers in various fields. AKG also influences several age-related processes, including stem cell proliferation and osteoporosis. To determine its role in mammalian aging, we administered CaAKG in 18 months old mice and determined its effect on the onset of frailty and survival, discovering that the metabolite promotes longer, healthier life associated with a decrease in levels of inflammatory factors. Interestingly the reduction in frailty was more dramatic than the increase in lifespan, leading us to propose that CaAKG compresses morbidity.
Calcium alpha-ketoglutarate is also a good phosphate binder and effectively treats secondary hyperparathyroidsm:
Miner Electrolyte Metab . 1996;22(1-3):196-9.
Long-term Treatment With Calcium-Alpha-Ketoglutarate Corrects Secondary Hyperparathyroidism
E Zimmermann, S Wassmer, V Steudle
Calcium-alpha-ketoglutarate (Ca-ket) is known as a highly effective phosphate (P) binder in hemodialysis (HD) patients. In addition, alpha-ketoglutarate has been shown to improve metabolic alterations. We investigated the effect of long-term P-binding therapy with Ca-ket to determine whether P accumulation is the main reason of secondary hyperparathyroidism (HPT) in HD patients or not. Ca-ket was prescribed to 14 HD patients as a soluble preparation in a mean dosage of 4.5 g/day (0.975 g elemental Ca) for a period of 36 months. Serum P continuously dropped from prestudy 2.6 +/- 0.1 (mean +/- SEM) to 1.9 +/- 0.07 mmol/l (p < 0.001), whereas serum Ca increased from 2.2 +/- 0.1 to 2.47 +/- 0.08 mmol/l (p < 0.05). Thus, Ca/P ratio in serum converted significantly from 0.91 +/- 0.02 (prestudy) to 1.28 +/- 0.01 (p < 0.001). Intact parathyroid hormone (iPTH) continuously normalized in all patients from 29 +/- 5 to 8 +/- 2 pmol/l (p < 0.001). The present data show that long-term treatment with Ca-ket normalizes secondary HPT by simultaneously P binding and correcting Ca/P ratio in serum without vitamin D treatment.
Alpha-ketoglutarate also lowers ammonia and has antioxidant functions. For review, see
Review Article | Open Access
Volume 2018 |Article ID 3408467 | 6 pages | The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
The Antioxidative Function of Alpha-Ketoglutarate and Its Applications
Shaojuan Liu,1,2 Liuqin He,1,2 and Kang Yao1
Academic Editor: Lidong Zhai
Received04 Jan 2018
Accepted19 Feb 2018
Published21 Mar 2018
Abstract
Alpha-ketoglutarate (AKG) is a crucial intermediate of the Krebs cycle and plays a critical role in multiple metabolic processes in animals and humans. Of note, AKG contributes to the oxidation of nutrients (i.e., amino acids, glucose, fatty acids) and then provides energy for cell processes. As a precursor of glutamate and glutamine, AKG acts as an antioxidant agent as it directly reacts with hydrogen peroxide with formation of succinate, water, and carbon dioxide; meanwhile, it discharges plenty of ATP by oxidative decarboxylation. Recent studies also show that AKG has alleviative effect on oxidative stress as a source of energy and an antioxidant in mammalian cells. In this review, we highlight recent advances in the antioxidative function of AKG and its applications in animals and humans.
Furthermore, it seems to have positive effect on the microbiome and to lower intestinal inflammation:
The effects of dietary supplementation with α-ketoglutarate on the intestinal microbiota, metabolic profiles, and ammonia levels in growing pigs - ScienceDirect
Europe PMC
Alpha-ketoglutarate suppresses the NF-κB-mediated inflammatory pathway and enhances the PXR-regulated detoxification pathway
Unfortunately, I couldn't find pure calcium alpha-ketoglutarate as a supplement. If anyone can find it let me know. The only products with calcium alpha-ketoglutarate I could find are the following:
Alpha Ketoglutaric Acid 300 mg - Hypoallergenic from Kirkman
Calcium AKG
https://rejuvant.com/f/Mens-Ingredients.jpg
They all contain problematic fillers.