Thank you!Oleic acid
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Thank you!Oleic acid
@haidut
I am very late to the game and am trying to learn a lot. I ordered 5a-DHP already and want to know if there is any reason 5a-DHP could be better or if it is inferior in all ways. Thank you!
What lab do you use to test the purity of your product after it has been synthesized?
As it seems allopregnanolone also has strong thyroid boosting effects ,aside from its anti-stress actions .
It agonizes the bile a of receptor TGR5 ,which increases energy expenditure, mostly via increasing T4 to T3 conversion .
I just dont know how much mg is needed to achieve micromolar concentrations of allopregnanolone.
"As shown in the present study, TGR5 is also expressed in astrocytes and neurons. Here, TGR5 may act as a neurosteroid receptor, which is activated by nanomolar concentrations of 5β-pregnan-3α-ol-20-one and micromolar concentrations of 5β-pregnan-3α-17α-21-triol-20-one and 5α-pregnan-3α-ol-20-one (allopregnanolone).
The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain - PubMed
TGR5 (Gpbar-1) is a membrane-bound bile acid receptor in the gastrointestinal tract and immune cells with pleiotropic actions. As shown in the present study, TGR5 is also expressed in astrocytes and neurons. Here, TGR5 may act as a neurosteroid receptor, which is activated by nanomolar...pubmed.ncbi.nlm.nih.gov
From that topic:" However, it is only able to do so at micromolar concentrations, which, similarly to the case of the L-VGCCs, are far greater than the low nanomolar concentrations of allopregnanolone estimated to be present in the brain.[15]"Yes, we have a thread on that topic.
How Pregnenolone And Progesterone Raise Metabolism
I know pregnenolone/progesterone work via multiple mechanisms such as inhibiting serotonin, opposing estrogen, lowering FFA, etc. However, this method caught my eye and I thought I'd share it since many people here have trouble converting T4 into T3. As you all know both pregnenolone and...raypeatforum.com
From that topic:" However, it is only able to do so at micromolar concentrations, which, similarly to the case of the L-VGCCs, are far greater than the low nanomolar concentrations of allopregnanolone estimated to be present in the brain.[15]"
So it seems unlikely to agonize this receptor with allopregnanolone.
hahahhah I would bet 50 bucks that's what he will say. Please post it here :)Nice , I ordered :)
also asked Peat what he thinks about direct allopregnanolone supplementation. I guess his answer will be:" just supplement progesterone or pregnenolone" , but we will see ...
Very nice haidut!! Thanks for keeping up the exciting work!
I have some questions:
1) Is there any risk of supressing endogenous allopregnanolone or anyother hormone synthesis?
2) Is there any risk of upregulating/downregulating any other neurotransmitter, neuropeptide or hormone pathways?
For instance, plain pregnenolone doesn't have any of these risks at any dose AFAWK (as far as we know here in RP forum).
3) I remember you saying some years ago in some posts that too much allopregnanolone could cause some feelings of aggression or anxiety (can't remember exactly). Do I recall correctly?
Edit : Yes, it has a Biphasic u-shaped action curve. Just saw it on wikipedia.
4) Can it have some "feminizing"/anti-androgenic effects like sometimes in some doses for some people progesterone/pregnenolone does?
Thanks a bunch!!!
Can't talk about risks/safety. That is against FDA rules. All I can say is that studies so far do not demonstrate suppression of endogenous synthesis of other steroids of neurotransmitters. There are no reports of hormonal effects either. Unlike progesterone, 5a-DHP, etc allopregnanolone seems to be similar to pregnenolone - i.e. mostly a neurosteroid, devoid of "classical" hormonal effects through receptors such as PR, ER, AR, GR, etc.
Does that also mean that it can not alter the menstrual cycle if taken at the wrong time of month like progesterone does?
Thanks haidut. Totally understand the FDA thing. From wikipedia :Can't talk about risks/safety. That is against FDA rules. All I can say is that studies so far do not demonstrate suppression of endogenous synthesis of other steroids of neurotransmitters. There are no reports of hormonal effects either. Unlike progesterone, 5a-DHP, etc allopregnanolone seems to be similar to pregnenolone - i.e. mostly a neurosteroid, devoid of "classical" hormonal effects through receptors such as PR, ER, AR, GR, etc.
is brexanolone just a patented form or what is the exact ingredients in brexanolone besides allopregnanolone? if you google brexanolone a wikipedia page for allopregnenolone comes upI can't legally make statements on this topic, but AFAIK the clinical trial with Brexanolone did not report issues with the menstrual cycle.
Mate does this not apply for things for lab usage. seems very restricted "In the United States, brexanolone is a Schedule IV controlled substance.[7][6] Allopregnanolone is available only through a restricted program called the Zulresso REMS Program that requires the drug to be administered by a healthcare provider in a certified healthcare facility. The REMS requires that patients be enrolled in the program prior to administration of the drug"I can't legally make statements on this topic, but AFAIK the clinical trial with Brexanolone did not report issues with the menstrual cycle.
Mate does this not apply for things for lab usage. seems very restricted "In the United States, brexanolone is a Schedule IV controlled substance.[7][6] Allopregnanolone is available only through a restricted program called the Zulresso REMS Program that requires the drug to be administered by a healthcare provider in a certified healthcare facility. The REMS requires that patients be enrolled in the program prior to administration of the drug"
also "Exogenous progesterone, such as oral progesterone, elevates allopregnanolone levels in the body with good dose-to-serum level correlations.[57] Due to this, it has been suggested that oral progesterone could be described as a prodrug of sorts for allopregnanolone"
is brexanolone just a patented form or what is the exact ingredients in brexanolone besides allopregnanolone? if you google brexanolone a wikipedia page for allopregnenolone comes up
Big pharma = 34 000$Brexanolone is just another name for allopregnanolone. As such, it cannot be patented directly, but the entire formulation - the steroid, adjuvants, solvents, IV bag, etc - that is administered to patients can be patented and has been patented under the trade name Zulresso.
Treat Postpartum Depression | ZULRESSO® (brexanolone) CIV
Learn about ZULRESSO®, an FDA-approved treatment for PPD in adults. See full Prescribing Information, Boxed Warning, and Important Safety Info.www.zulresso.com