It is a well-known complication of a glucose drip that the veins calcify and become unusable if many bags are done in same place. Sugar is most certainly damaging according to concentration.From Schultz
"Me:
It is said hyperglycemia is bad because it can cause damage to nerves, blood vessels, organs. Do you think the sugar itself can cause damage if its level is kept high in the
blood stream for an extended period? There is a lot going on when the body is in a state of hyperglycemia, so it seems a little bit weird to blame any damage that is caused entirely on the sugar itself. Could it just be something else that happens to be high like FFA, insulin, lactic acid, or even an absence of something, like sugar (being utilized) or CO2?
Ray:
"In tissue culture experiments, very high glucose has harmful effects, but those conditions don’t reflect what happens in the whole organism. Glucose in the blood is increased adaptively to protect against something that’s damaging the tissues, and that’s usually a hormone imbalance that is interfering with the ability to oxidize glucose. The “glycation” that’s usually blamed on high glucose is mostly caused by lipid peroxidation from polyunsaturated fats, and the glycerol that’s liberated by lipolysis, and metabolized to methylglyoxal. The fats block glucose metabolism for energy, and more glucose is produced to overcome that.""
The interview had many good nuggets of knowledge, so thanks to haidut and danny for doing these!