tlr

  1. haidut

    Another "paradox" - glucocorticoids cause inflammation, insulin blocks it

    As many of my readers know, I am not a fan of the ubiquitous usage of both bioidentical and synthetic glucocorticoids (GC) in medicine. Once used only in the most severe cases, some form of GC therapy awaits virtually all patients in a hospital (regardless of condition), and doctors are now...
    • haidut
    • Thread
    • cortisol endotoxin glucocorticoid inflammation insulin lps tlr tlr4
    • Replies: 4
    • Forum: Scientific Studies
  2. Hans

    The Gut-Hair Loss Connection: Fix The Gut To Stop Hair Loss

    Hi all, The gut is truly involved with just about everything in the body, however, few actually know that their gut health is contributing to their hair health. So many people might experience gut issues, but seldom connect it to their hair loss. I have written an article to shed some light on...
  3. haidut

    Endotoxin Has A G.E.L.D.I.N.G Effect, Causes Obesity And Hypogonadism

    A very interesting study proposing that the decline in gonadal function seen in obese/diabetic men is due to chronically elevated endotoxin levels in such people. The study calls this phenomenon (G)ut (E)dotoxin (L)eading to a (D)ecline (I)n (G)onadal function (GELDING) due to the remarkable...
    • haidut
    • Thread
    • castration diet endotoxin gelding high-fat hypogonadism inflammation leydig lps obesity tlr tlr4
    • Replies: 34
    • Forum: Scientific Studies
  4. haidut

    Allopregnanolone As A Treatment Of Alzheimer Disease (AD)

    It looks like the recent FDA approval of allopregnanolone (ALLO) for postpartum depression may open the floodgates to ton of new research with this steroid, as well as with its reliable precursors such as pregnenolone and progesterone. I posted several studies in the past demonstrating that...
    • haidut
    • Thread
    • ad allo allopregnanolone alzheimer's endotoxin energy inflammation lps metabolism pregnenolone progesterone tlr tlr4 treatment
    • Replies: 0
    • Forum: Scientific Studies
  5. haidut

    Chronic Nerve Pain May Be Caused By Endotoxin, Commercial Food, And Pharma Drugs

    I posted a few threads last year demonstrating that some cases of chronic nerve pain may be caused by a side effects of opioids - activation of TLR4. However, that study only looked at why certain patients using opioids for severe pain go on to develop chronic pain of phantom origin. As such...
    • haidut
    • Thread
    • commercial food endotoxin iatrogenic inflammation lps lysozyme nerve pain neuropathy pharmaceutical drugs tlr tlr4
    • Replies: 5
    • Forum: Scientific Studies
  6. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
    • haidut
    • Thread
    • endotoxin energy fao fas fasn fatty acid oxidation fatty acid synthase infection inhibit inhibitor randle cycle sepsis tlr tlr4
    • Replies: 6
    • Forum: Scientific Studies
  7. haidut

    Progesterone May Bind And Deactivate Endotoxin (LPS) Directly

    I made a few posts recently discussing the blocking effects of pregnenolone on TLR4 and TLR family receptors in general, and the reduction of systemic inflammation stemming from this blockade/regulation...
    • haidut
    • Thread
    • bind block covalent deactivate endotoxin histamine inflammation lps pregnenolone progesterone react serotonin tlr tlr4
    • Replies: 15
    • Forum: Scientific Studies
  8. haidut

    MS Tied To Glucose Deficiency Due To Endotoxin And Fat, Extra Glucose May Treat It

    Just a few days ago I posted the groundbreaking study on metabolic derangement in ALS - i.e. it is a diseased characterized by increased FAO, which wastes glucose. Simply increasing dietary glucose was able to greatly restrain the pathology...
    • haidut
    • Thread
    • ceramides fao fatty acid oxidation glucose insulin resistance lps mitochondria mitochondrial function ms multiple sclerosis randle cycle tlr tlr4
    • Replies: 48
    • Forum: Scientific Studies
  9. haidut

    Endotoxin (LPS) Linked To Lower Survival In Cancer

    Another study about endotoxin, this time linking higher sensitivity to endotoxin to lower survival chance for people with lymphoma. While the study below looked at only one cancer, there are multiple studies with other cancer that have found similar link. Endotoxin and cancer go hand in hand...
    • haidut
    • Thread
    • cancer cause endotoxin exacerbate lps lymphoma mortality tlr tlr4
    • Replies: 2
    • Forum: Scientific Studies
  10. haidut

    Blocking Endotoxin (LPS) May Reverse/cure Diabetes Type I

    Yet another study demonstrating the key role of endotoxin in the pathology of perhaps the most widespread chronic disease - diabetes. The study below discovered that the proliferation of the insulin-producing beta-cells in the pancreas is controlled almost entirely by the TLR4/TLR2 receptor...
    • haidut
    • Thread
    • beta-cells cause diabetes endotoxin inflammation insulin lps pancreas tlr tlr2 tlr4
    • Replies: 5
    • Forum: Scientific Studies
  11. haidut

    Endotoxin (LPS) May Cause Depression / Anhedonia

    As many readers know, anhedonia is one of the most pernicious aspects of clinical depression. It is present in other mental health conditions but is most pronounced and severe in clinical unipolar depression. It is also especially resistant to treatment and many doctors simply accept it as...
    • haidut
    • Thread
    • anhedonia cause depression endotoxin inflammation lps tlr tlr4
    • Replies: 31
    • Forum: Scientific Studies
  12. haidut

    Pancreatic Cancer Driven By Bacteria/endotoxin; Antibiotics Can Prevent/treat

    I just posted a seminal study showing that possibly ALL autoimmune conditions may be caused by a chronic low-grade infection. This infection stems from a gut bacteria, which has translocated from the gut to the liver/lymphs due to compromised gut barrier and lingers there chronically thus...
    • haidut
    • Thread
    • ampicillin antibiotics bacteria bifidobacterium cancer cause endotoxin gut gut permeability lps microbiome pancreas pancreatic cancer tlr tlr4 tlr6 translocation
    • Replies: 15
    • Forum: Scientific Studies
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