sirtuin

  1. haidut

    Niacinamide may prevent neurodegeneration

    Yet another study demonstrating that maintaining high energy levels through OXPHOS is crucial for health, in this case brain health. There are many studies, going back decades, demonstrating that a drop in NAD+ levels, and thus of NAD/NADH and, consequently, of OXPHOS is a common feature of...
  2. David PS

    Natural polyphenols as sirtuin 6 modulators

    Natural polyphenols as sirtuin 6 modulators (2018) Sirtuin 6 - Wikipedia For my purposes, I think of SIRT6 as the Infrastructure Sirtuin. Here in the US, our infrastructure (roads and bridges) is crumbling and our aging infrastructure is in need of repair. SIRT6 is involved in...
  3. haidut

    Niacinamide may treat lymphoma

    A very interesting study and a "synchronicity" event as well, considering the recent in-vivo experiments I conducted with a combination of vitamin B1 and vitamin B3 (niacinamide) in a mouse xenograft model of human mantle-cell lymphoma. In that experiment of mine, HED of 15mg/kg B1 and 30mg/kg...
  4. haidut

    Keto (low-carb) diet causes heart fibrosis, blocks mitochondrial biogenesis

    The bad news for the low-carb / keto community keep piling on. There are a number of posts on this blog about studies demonstrating insulin resistance, diabetes, obesity and even sarcopenia as a result of low-carb diets or their close mimetic known as intermittent fasting. Now, the study below...
  5. haidut

    SIRT1 Is A Key Promoter Of Leukemia And Other Blood Cancers

    SIRT1 (one of the sirtuin genes) is currently one of the stars in the nutritional/medical blogosphere. As far as back as 2004, SIRT1 was promoted as a key regulator of longevity and activating this gene was marketed as one of the most reliable ways of increasing lifespan. Resveratrol was lauded...
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