1. haidut

    Niacinamide may treat depression by improving energetic state

    A very interesting study, sent to me by a collaborator who lives in Austria. It demonstrated that depression is accompanied by increased SIRT1 activity (i.e. increased fatty acid oxidation), lower ATP levels and redox balance shifted towards reduction. The study demonstrated that animals without...
  2. haidut

    Acidosis (Warburg Effect) Drives Cancer Through Increased Fat Oxidation (Randle Cycle)

    The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...
  3. haidut

    SIRT1 Is A Key Promoter Of Leukemia And Other Blood Cancers

    SIRT1 (one of the sirtuin genes) is currently one of the stars in the nutritional/medical blogosphere. As far as back as 2004, SIRT1 was promoted as a key regulator of longevity and activating this gene was marketed as one of the most reliable ways of increasing lifespan. Resveratrol was lauded...
  4. P

    Biotin Accumulate In Adipose Tissue With Aging?(study) Biotin Inhibit Sirt1

    what do you think? Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice SIRT1, a longevity regulator and NAD+-dependent deacetylase, plays a critical role in promoting metabolic fitness...
  5. haidut

    Niacinamide Is Androgenic And Increases Dht Effects/signaling

    I just posted a study showing that inhibition of SIRT1 is anti-estrogenic, and SIRT1 inhibitors like niacinamide have similar effects to the estrogen receptor antagonist fulvestrant. Niacinamide Is Anti-estrogenic | Ray Peat Forum This study shows that, again through inhibition of SIRT1...
  6. haidut

    Niacinamide Is Anti-estrogenic

    Yet another strong point for niacinamide. I am beginning to wonder if there is any condition or biomarker of disease that niacinamide cannot affect. Peat has written many times about the sirtuin genes and their promoter resveratrol. While there is already quite a bit of evidence that SIRT1...
  7. haidut

    Niacinamide Lowers Fatty Acid Oxidation By Inhibiting SIRT1

    Many of you have probably heard of the resveratrol "miracle pill", which works by activating the SIRT1 "longevity gene". Well, the whole story is a classic example of medical fraud, and resveratrol was a miserable failure in clinical trials. This is not surprising to me as resveratrol has...
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