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fas

  1. A

    Inhibition of fatty acid synthesis blocks SARS-CoV-2 replication

    Caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), COVID-19 is a virus-induced inflammatory disease of the airways and lungs that leads to severe multi-organ damage and death. Here we show that cellular lipid synthesis is required for SARS-CoV-2 replication and offers an...
  2. haidut

    Melanoma Defined By Increased Fatty Acid Synthesis And Unsaturation

    Yet another study implicating dysregulated fatty acid, instead of glucose, metabolism in cancer cells. Namely, the expression and activity of the enzyme fatty acid synthase (FASN) is increased in melanoma cells. Another interesting finding of the study is the increased unsaturation of the...
    • haidut
    • Thread
    • cancer desaturase fas fasn fatty acid synthase melanoma mufa unsaturation
    • Replies: 0
    • Forum: Scientific Studies
  3. haidut

    Increased Fatty Acid Synthesis (FAS) Is Simply A Sign Of Oxygen Deficiency / Low Metabolism

    Just a quick post on a study that provides insight as to how increased fatty acid oxidation (FAO) can "paradoxically" result in increased FAS as well, thus leading to a vicious cycle most commonly seen in diabetes and cancer. One of my recent posts discussed a much more recent study that...
    • haidut
    • Thread
    • cancer diabetes electron flow fao fas fasn nad nadh oxidation oxphos oxygen randle cycle terminal electron acceptor
    • Replies: 3
    • Forum: Scientific Studies
  4. haidut

    Acidosis (Warburg Effect) Drives Cancer Through Increased Fat Oxidation (Randle Cycle)

    The evidence continues to pile on that naming the (in)famous observation made by Otto Warburg in regards to cancer an "effect" is one of the most profound falsehoods the medical profession has ever concocted. Almost a century after the Warburg "Effect" term was coined, the evidence rapidly...
    • haidut
    • Thread
    • acidosis aspirin cancer cause drive fao fas fasn lactate metabolic disease niacinamide randle cycle sirt sirt1 sirt6 warburg effect warburg-randle warburg-randle cycle
    • Replies: 7
    • Forum: Scientific Studies
  5. haidut

    Inhibiting Fatty Acid Synthesis (FAS) Dramatically Improves Sepsis Survival Rate

    Yet another study that points the finger straight at fat as a key factor in one of the most common causes of inpatient hospital mortality - sepsis. Sepsis is currently considered to be a condition of infectious (bacterial) etiology, driven by endotoxin. However, in light of the new findings it...
    • haidut
    • Thread
    • endotoxin energy fao fas fasn fatty acid oxidation fatty acid synthase infection inhibit inhibitor randle cycle sepsis tlr tlr4
    • Replies: 6
    • Forum: Scientific Studies
  6. haidut

    Synthetic Progestins Are Estrogenic And Promote Cancer Through FAS

    As many forum users know, the debate over the role of progesterone in breast cancer has been raging since the 1950s when the first synthetic progestins hit the market. Peat is strong proponent of the beneficial and anti-cancer effects of bioidentical progesterone, while at the same time voicing...
    • haidut
    • Thread
    • 19-norprogesterone cancer er estrane estrogen receptor estrogenic fas fatty acid synthesis growth medroxiprogesterone acetate megestrol acetate norethindrone norethynodrel norprogesterone promote synthetic progestin
    • Replies: 4
    • Forum: Scientific Studies
  7. haidut

    Liver Disease Is Caused By Low ATP Driven By Fat (PUFA) Oxidation

    I posted a study several months ago on the ability of inosine to prevent/reverse liver disease, and how liver damage caused by various toxins was due to lower ATP levels in the liver. Inosine, being both a metabolite and precursor of ATP, is able to restore ATP levels and as such to...
    • haidut
    • Thread
    • atp cardiolipin cirrhosis fao fas fatty acid oxidation fatty acid synthesis liver liver disease mitochondrial dysfunction nafld nash peroxidation pufa
    • Replies: 25
    • Forum: Scientific Studies
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