Salty
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- Sep 8, 2015
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Salty said:post 100308 That's everything. Please post for discussion if anyone finds anything particularly interesting among these documents.
Salty said:post 100346 Diphtheria-pertussis-tetanus (DPT) immunization: a potential cause of the sudden infant death syndrome (SIDS)
Salty said:post 100390 One more note on this topic, that brings a Peat angle into all this:
"Could Serotonin Play a Role in Sudden Infant Death?"
(http://www.nature.com/pr/journal/v65/n2 ... 0926a.html)
From the article:
"The triple-risk model for the pathogenesis of SIDS proposed by Kinney and coworkers (2) proposes that sudden death results when three risk factors occur simultaneously: 1) an underlying vulnerability; 2) a critical period for homeostatic control; and 3) an exogenous stressor. The underlying vulnerability remains latent until the infant enters a critical developmental period (the first 6 mo of life when 90% of SIDS deaths occur) and is exposed to an exogenous stressor."
In regards to serotonin it says,
" Immunohistochemical analysis revealed an increased number of serotonin neurons, as well as an increase in the fraction of serotonin neurons showing an immature, granular cell morphology suggesting a failure or delay in the maturation of these neurons in SIDS infants."
Haidut, can you help me understand if this means the infants had increased serotonin? I'm trying to understand exactly what they're saying here.
I would love to see a study that looks at the full metabolic effects of vaccination, and not just whether or not antibody is induced - the broader nonspecific effects as discussed above. Could a vaccine be "an exogenous stressor"? They certainly force an exaggerated immune response through the use of toxic adjuvants (aluminum mostly), during an immunologically vulnerable age.
Salty said:post 100660 Thank you for the explanation, Haidut . You are much more well versed in endocrinology than I. This thread has inspired me to look more into the potential metabolic effects of vaccines. I haven't found a whole lot so far other than some old studies on pertussis toxin containing vaccines that dramatically increase sensitivity to histamine and, guess what... serotonin, which may or may not have any relationship with the above. I'm still trying to make some sense of this and related papers, but for any one else interested here is a link and quick quote:
The altered reactivity of mice after inoculation with Bordetella pertussis vaccine. (Kind, 1958):
“For many years the effects of bacterial inoculations have been described chiefly in terms of the antibody response of the host. Recent investigations [1958! - emphasis mine], however, have indicated that nonspecific changes in resistance to infection can follow the injection of various bacterial products into a suitable animal. Perhaps the most unusual and most dramatic modifications of response occur in mice injected with Bordatella pertussis vaccine. These animals become exceedingly susceptible to the lethal effects of histamine, serotonin, anaphylaxis, and gram-negative bacterial vaccines as well as to other agents and conditions..."
The only human study (abstract) I have found so far is one with children from 1974 that also noted a "remarkable increase" in histamine sensitivity, most marked in day 5-7 post DPT immunization. The abstract makes no mention of any increase in sensitivity to serotonin.
Studies of adrenergic mechanisms inrelation to histamine sensitivity in children immunized with Bordetella pertussis vaccine (Sen, 1974)
A lot of the older studies ask if such effects also occur in humans (and at what metabolic cost), but it seems like research into such seemingly essential questions ran dry long ago. Anyhow, interesting stuff to ponder.
Salty said:post 100679 Perhaps. That may be of some value in mitigating potential allergy issues implicated with vaccination. Though the histamine sensitization is only one of the effects of pertussis toxin containing vaccines noted in this and related papers, so not sure how much effect an antihistamine would have on the other effects (like serotonin sensitivity). Plus, it may be that these specific effects apply only to pertussis and not other vaccines.
Whats desperately needed, imo, are studies that look at the full short- and long- term metabolic effects of each vaccine individually as well as in all the combinations given (any synergistic effects?). Not to mention all the variance introduced by the many different manufacturing processes by all the major vaccine producers.