Progesterone Raises SHBG

[DaveFoster]

The effect of progesterone administration on sex hormone binding globulin binding capacity in women with severe premenstrual syndrome. - PubMed - NCBI

Thirty-one women with severe premenstrual syndrome had low sex hormone binding globulin (SHBG) binding capacities 30.2 +/- 9.4 nmol DHT bound/l. The SHBG binding capacities rose when they were treated with three different doses of progesterone. On 400 mg (17 women) SHBG level was 45.11 +/- 11.80. On 800 mg (8 women) SHBG binding capacity rose to 64.75 +/- 14.30 and on the six women who took 1200 mg progesterone daily SHBG binding capacity was 78.5 +/- 23.10. These results are discussed.

They used large dosages in this study, and since progesterone takes away estrogenic symptoms even for men, it likely lowers estrogen more than it lowers testosterone in men.

 

[Drareg]

Nice find.
Seems like a pro and a con depending on the context.

 

[DaveFoster]

@Drareg

I agree; I think maybe if estrogenic symptoms are present like gyno or something like cancer, it would be beneficial.

I wonder if lower dosages would have the same effect on SHBG.

 

[Progesterone]

There we go...