Mauritio
Member
- Joined
- Feb 26, 2018
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If somebody decides to take doxorubicin or another chemotherapy drug for whatever reason, then it seems smart to take pregnenolone with it. Doxorubicin is known for having a lot of side effects on the heart :
"The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500–550 mg/m2, 18% when the dose is 551–600 mg/m2 and 36% when the dose exceeds 600 mg/m2.[17] "
This study shows that preg was able to strongly alleviate those side effects by lowering oxidative stress and MMP2. MMP2 has been implicated in cancer and is biomarker for covid mortality, so its good to lower that.
The HED was around 400-500mg.
- Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis-Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1 - PubMed
- Doxorubicin - Wikipedia
"The rate of cardiomyopathy is dependent on its cumulative dose, with an incidence about 4% when the dose of doxorubicin is 500–550 mg/m2, 18% when the dose is 551–600 mg/m2 and 36% when the dose exceeds 600 mg/m2.[17] "
This study shows that preg was able to strongly alleviate those side effects by lowering oxidative stress and MMP2. MMP2 has been implicated in cancer and is biomarker for covid mortality, so its good to lower that.
The HED was around 400-500mg.
- Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis-Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1 - PubMed
- Doxorubicin - Wikipedia