Doxylamine Succinate - Cognitive Enhancer

[DaveFoster]

After experimenting with doxylamine succinate to induce sleep (6 mg), I've noticed that my ability to focus has increased tremendously, mostly due to diminsihed anxiety.

Psychiatrists prescribe antihistamines as anti-anxiety alternatives to benzodiazepines or SSRI's, and haidut has mentioned the ability of anticholinergics to improve ADHD symptoms considerably and result in a net lower serotonin. Appetite has also increased with the addition of doxylamine, similar to cyproheptadine.

 

[Drareg]

is it better than Cypro in your opinion or too early to tell? Did Peat mention it anywhere?

 

[Bluebell]

I've been wondering about trying doxylamine succinate for sleep. Does it work better that Cypro for that, for you?

 

[ecstatichamster]

any follow up on this @DaveFoster ? You are da man!

 

[DaveFoster]

is it better than Cypro in your opinion or too early to tell? Did Peat mention it anywhere?

It's a stronger anthistamine than cypro. It's pretty safe, so I recommend giving it a go.

I've been wondering about trying doxylamine succinate for sleep. Does it work better that Cypro for that, for you?

It did seem to work better, but I still had trouble falling asleep. It's superior to Benadryl IMO, but cypro has a relaxing kind of stimulation, while doxylamine has more pronounced sedation.

any follow up on this @DaveFoster ? You are da man!

I haven't used it since, but it made me feel very good the day after. I'll touch it again, but I have a few antihistamines floating around my system, so I'll wait.

 

[Peata]

@DaveFoster how long did you take doxy nightly before you noticed the enhanced focus?

 

[DaveFoster]

@DaveFoster how long did you take doxy nightly before you noticed the enhanced focus?

Just one night. 2-4 mg.

 

[Oniyogini]

I actually prefer ¼ Doxy- sold as Restamine in Australia, it is banned in the UK, chemist told me reason due to the K Kardashian thing- because it doesn't leave me groggy like Cypro does. My muscles feel pretty relaxed too. We have all three : Doxy, Cypro and DiphenH in the house as I cycle them for different needs. My hubby prefers Cypro, the other two don't seem to make him fall asleep unless he takes a whole Doxy; I use DiphenH for pollen allergy and insect bite inflammation- I swell up from any thing that bites- and Cypro ¼ pill if I don't have to go anywhere the next day. For me Doxy is great for jetlag too.

 

[Peata]

Just one night. 2-4 mg.

Ok, thanks. I have some but only take it once in a while, usually 1/4-1/3 tablet. Might take it a little more regularly.

 

[DaveFoster]

Apparently doxylamine has a dangerous interaction with methylene blue, so more information conerning it's serotonergic activity is needed.

 

[Israelibacon]

@DaveFoster how did you manage to get 6mg Doxy? I assume you took a 25mg tab and cut it into 4?

 

[DaveFoster]

@DaveFoster how did you manage to get 6mg Doxy? I assume you took a 25mg tab and cut it into 4?

Yes.

 

[Israelibacon]

Yes.

Thank you :)

 

[hotte]

How about tolerance building? Especially if you take it for sleep issues.

 

[Mauritio]

How about tolerance building? Especially if you take it for sleep issues.

I didnt develop a tolerance . At least not so much that i could feel it. Took 6 mg for 2 weeks . I suspected some liver issues but it could also come from stress that i had at that time ...
Also in my experience with high gut serotonin i dont think its a strong serotonin antagonist ...

 

[TheAnarchist]

Is doxylamine bad for anhedonia? It seems to have possibly made it worse for me whereas cyproheptadine made it better. I have been using both for sleep but my anhedonia was better with cypro by itself, doxylamine seems to undo a lot of the good. Does this make any logical sense?