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haidut said:post 82207 In general, pro-dopamine drugs like cyproheptadine would be sedating. This is confirmed by the sedating properties of drugs like lisuride, bromocriptine, cabergoline, etc.
barefooter said:post 118487haidut said:post 82207 In general, pro-dopamine drugs like cyproheptadine would be sedating. This is confirmed by the sedating properties of drugs like lisuride, bromocriptine, cabergoline, etc.
I thought I'd read on the forums before about cypro lowering dopamine. Am I mistaken, or can prolonged use of it actually lower dopamine?
mujuro said:post 118656 Central H1 receptor antagonism.
EDIT - actually I just found this on the wiki page.
The expression of NF-κB, the transcription factor that regulates inflammatory processes, is promoted by the constitutive activity of the H1 receptor as well as by agonists that bind at the receptor.[3] H1-antihistamines have been shown to attenuate NF-κB expression and mitigate certain inflammatory processes in associated cells.[3]
Interesting. I'm sure haidut has probably already covered this in the main cypro thread.
Yeah, it either wears off or the person gets used to it. I think in my case it's a combination of both: I got used to it but it's a milder sedation now.Doesn't the sedation effect of Cypro wear off though after days, or weeks on it?
Caffeine also stimulates orexin , I hope that doenst mean it also stimulates histamine...There is a relationship between histamine and the orexin/hypocretin system that promotes wakefulness.
Interactions of the orexin/hypocretin neurones and the histaminergic system.
Caffeine also stimulates orexin , I hope that doenst mean it also stimulates histamine...
Stimulant doses of caffeine induce c-FOS activation in orexin/hypocretin-containing neurons in rat. - PubMed - NCBI
Also serotonin lowers orexin , but does that mean that orexin also lowers serotonin ?
You just assume it's just a little. And a little might be a little too much for someone who already has too much histamine. Also histamine raises estrogen and inflammation.
The need might be there (liver benefits) but the practicality of it might be difficult that's right.Someone that already has too much histamine has no need for caffeine for its most common use which is to promote wakefulness and alertness.
Cypro's antidopaminergic effect is so strange. I feel heavy anticholinergic and antihistamine effect of cypro over first week, which are very unpleasant, but then It feels so prodopamine or at least antiinflammatory and antidepressant. And there are only few studies on Cypro's antidopaminergic properties and their's content is very abstract. if you look at books about antihistamines in general, then not a word will be said about the antidopaminergic activity of cypro. Unless research with rat receptors. It is so strange that such a weighty effect for the pharmacological context of such an old drug has not been investigated with cloned human receptors or with the help of radionuclides on living people.It seems to depend on the person and the dose. In lower doses of 4mg daily cyproheptadine will probably not affect dopamine. I also know people who take 24mg daily and their prolactin went down.
In addition prohistamine action of fasting is maybe the maine reason of euphoric and arosual fasting effectWhat's wrong with a little more histamine? Histamine is a very vital neurotransmitter. Caffeine increases glutamate which will activate histaminergic neurons and help promote wakefulness seeing as histamine has an important role in that. I also read of caffeine blocking DAO to some degree. Orexin also is needed for histamine.
Caffeine promotes glutamate and histamine release in the posterior hypothalamus
THE REGULATION OF SLEEP AND WAKEFULNESS BY THE HYPOTHALAMIC NEUROPEPTIDE OREXIN/HYPOCRETIN
A lot of us aren't using coffee as stimulator, just more like strong protective and antiinflammatory agentSomeone that already has too much histamine has no need for caffeine for its most common use which is to promote wakefulness and alertness.