Mauritio
Member
- Joined
- Feb 26, 2018
- Messages
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Good news for the anti-aging crowd: Selegiline also works as an anti-aging drug in dogs.
Now it has been shown to be effective in four different species (hamsters, rats, mice and dogs), which shows that it acts on a fundamental, evolutionary conserved mechanism, which makes it more likely that it works in humans as well.
The interesting thing about this study is that they drug was effective, eventhough they started supplememtating the dogs in pretty old age, 10-15 years of age, which corresponds to around 60-90 years of age for a human.
Only half as many of the selegiline-dogs died, by the end of the study, as the control group.
Once again it seems to function in a way to primarily prevent premature death, which was already shown in rats, as I have written about here (Selegiline Experiences)
Now the dosage was pretty high ,not sure why and the number of dogs wasnt huge, but overall it is a very interesting study and I'm happy to see more research on that topic.
“To assess whether L-deprenyl treatment begun in later life might enhance canine longevity in a fashion similar to that documented in rodents we also examined survival in a subset of elderly dogs who were between the ages of 10 and 15 yrs at the start of tablet administration and who received tablets for at least 6 months. In this subset, dogs in the L-deprenyl group survived longer (p < 0.05) than dogs in the placebo group. Twelve of 15 (80%) dogs in the L-deprenyl group survived to the conclusion of the study, in contrast to only 7 of 18 (39%) of the dogs who received placebo (P=0.017). Furthermore, by the time the first L-deprenyl treated dog died on day 427, 5 placebo treated dogs had already succumbed, the first on day 295. Specifically with respect to dogs, the findings reported herein suggest daily oral administration of 1 mg/kg L-deprenyl prolongs life when begun in relatively healthy dogs 10-15 years of age and maintained for the duration of the individual’s life, but in any event for no less than six months.”
- Treatment with L-deprenyl prolongs life in elderly dogs - PubMed
Now it has been shown to be effective in four different species (hamsters, rats, mice and dogs), which shows that it acts on a fundamental, evolutionary conserved mechanism, which makes it more likely that it works in humans as well.
The interesting thing about this study is that they drug was effective, eventhough they started supplememtating the dogs in pretty old age, 10-15 years of age, which corresponds to around 60-90 years of age for a human.
Only half as many of the selegiline-dogs died, by the end of the study, as the control group.
Once again it seems to function in a way to primarily prevent premature death, which was already shown in rats, as I have written about here (Selegiline Experiences)
Now the dosage was pretty high ,not sure why and the number of dogs wasnt huge, but overall it is a very interesting study and I'm happy to see more research on that topic.
“To assess whether L-deprenyl treatment begun in later life might enhance canine longevity in a fashion similar to that documented in rodents we also examined survival in a subset of elderly dogs who were between the ages of 10 and 15 yrs at the start of tablet administration and who received tablets for at least 6 months. In this subset, dogs in the L-deprenyl group survived longer (p < 0.05) than dogs in the placebo group. Twelve of 15 (80%) dogs in the L-deprenyl group survived to the conclusion of the study, in contrast to only 7 of 18 (39%) of the dogs who received placebo (P=0.017). Furthermore, by the time the first L-deprenyl treated dog died on day 427, 5 placebo treated dogs had already succumbed, the first on day 295. Specifically with respect to dogs, the findings reported herein suggest daily oral administration of 1 mg/kg L-deprenyl prolongs life when begun in relatively healthy dogs 10-15 years of age and maintained for the duration of the individual’s life, but in any event for no less than six months.”
- Treatment with L-deprenyl prolongs life in elderly dogs - PubMed
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