- Joined
- Nov 14, 2014
- Messages
- 696
Doesn't niacinamide deplete methyl donors?
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Fish collagen should be safely free of glysophates.Nonetheless, I still would prefer to use a product that is labeled "Glyphosate-Free"
It would depend on what fish it is where it's extracted from. What if it's farm-raised tilapia?Fish collagen should be safely free of glysophates.
Looks like serine is more problematic, and whether glycine can be an issue depends on methyl donor availability
Serine, but Not Glycine, Supports One-Carbon Metabolism and Proliferation of Cancer Cells
Previous work has shown that some cancer cells are highly dependent on serine/glycine uptake for proliferation. Although serine and glycine can be interconverted and either might be used for nucleotide synthesis and one-carbon metabolism, we show that exogenous glycine cannot replace serine to support cancer cell proliferation. Cancer cells selectively consumed exogenous serine, which was converted to intracellular glycine and one-carbon units for building nucleotides. Restriction of exogenous glycine or depletion of the glycine cleavage system did not impede proliferation. In the absence of serine, uptake of exogenous glycine was unable to support nucleotide synthesis. Indeed, higher concentrations of glycine inhibited proliferation. Under these conditions, glycine was converted to serine, a reaction that would deplete the one-carbon pool. Providing one-carbon units by adding formate rescued nucleotide synthesis and growth of glycine-fed cells. We conclude that nucleotide synthesis and cancer cell proliferation are supported by serine—rather than glycine—consumption.
If you think the only thing glycine is used for is to make glutathione (and it isn't), and that the only use for glutathione is to protect cancer cells, then stopping glycine intake is like a doctor telling people to stop eating high purine foods just because it will increase uric acid production, as if uric acid is what's causing gout (overlooking the fact that uric acid is a protective anti-oxidant that is increased when the body needs it, and that the gout is caused by high ecf acidity, which causes uric acid to precipitate and cause joint pain and inflammation).What I don't understand about this is that glycine along with cysteine is used to make glutathione. As discussed here Blocking Cystine, And Thus Glutathione (GSH) Synthesis, Kills Cancer Stem Cells cancer cells use glutathione to protect themselves.
Isn't glycine going to push the body towards a more reduced state? If this is the case how is it protective against cancer?