Diokine
Member
- Joined
- Mar 2, 2016
- Messages
- 624
Treatment of mast cells with carbon dioxide suppresses degranulation via a novel mechanism involving repression of increased intracellular calcium levels.
Results from this study provide the first evidence of a unique regulatory mechanism by which CO₂ inhibits mast cell degranulation and histamine release by repressing stimulated increases in intracellular calcium. Thus, our data provide a plausible explanation for the reported therapeutic benefit of noninhaled intranasal delivery of 100% CO₂ to treat allergic rhinitis.
Influence of hyposensitization of ATP level and CO2 production of mast cells in anaphylaxis.
There has been a lot of talk on histamine lately, which I think is a good thing because of it's broad implications in health. I'm putting together an article currently that discusses the role of histamine and serotonin in the body. The takeaway point is that conditions like food sensitivity, allergies, and even anaphylaxis can be explained bioenergetically. This can explain why people who have low metabolic status (thyroid function, nutrient levels, etc.,) tend to be very sensitive to histamine. Additionally, genetic polymorphisms in diamine oxidase (the enzyme that breaks down histamine) can cause higher levels of histamine.
Histamine works by setting up the cell for stress. A structural change occurs that causes the cell to take up calcium and "swell" with water. CO2 production drops and energy production is greatly diminished. With this information, it is easy to see that improving whole body energetics cannot happen effectively without a proper understanding of the stress reaction, and how histamine plays a large part in that reaction.
CO2 elimination by high-frequency oscillations in dogs--effects of histamine infusion.
Carbon dioxide balance in rat stomach and peripheral tissue: effects of histamine.
The action of carbon dioxide on constricted airways.
Results from this study provide the first evidence of a unique regulatory mechanism by which CO₂ inhibits mast cell degranulation and histamine release by repressing stimulated increases in intracellular calcium. Thus, our data provide a plausible explanation for the reported therapeutic benefit of noninhaled intranasal delivery of 100% CO₂ to treat allergic rhinitis.
Influence of hyposensitization of ATP level and CO2 production of mast cells in anaphylaxis.
There has been a lot of talk on histamine lately, which I think is a good thing because of it's broad implications in health. I'm putting together an article currently that discusses the role of histamine and serotonin in the body. The takeaway point is that conditions like food sensitivity, allergies, and even anaphylaxis can be explained bioenergetically. This can explain why people who have low metabolic status (thyroid function, nutrient levels, etc.,) tend to be very sensitive to histamine. Additionally, genetic polymorphisms in diamine oxidase (the enzyme that breaks down histamine) can cause higher levels of histamine.
Histamine works by setting up the cell for stress. A structural change occurs that causes the cell to take up calcium and "swell" with water. CO2 production drops and energy production is greatly diminished. With this information, it is easy to see that improving whole body energetics cannot happen effectively without a proper understanding of the stress reaction, and how histamine plays a large part in that reaction.
CO2 elimination by high-frequency oscillations in dogs--effects of histamine infusion.
Carbon dioxide balance in rat stomach and peripheral tissue: effects of histamine.
The action of carbon dioxide on constricted airways.