CreakyJoints
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- Joined
- Mar 30, 2020
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- 304
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Oh, no worries at all! Thank you for all your thoughtful replies so far.Sorry I cant help you with that.
Fascinating study! Thanks much for the find.Consumption of fish oil high-fat diet induces murine hair loss via epidermal fatty acid binding protein in skin macrophages
Figure 1:Female mice | Figure S1:Male mice |
Figure 4A |
Figures 3K and 3L |
interesting!mice treated with anti-TNF-a antibody successfully recovered from fish oil HFD-induced hair loss
Thanks!Fascinating study! Thanks much for the find.
I think it is well-constructed in terms of precisely isolating the mechanism of how and why n-3's affect hair loss. The authors were very careful in eliminating unrelated pathways suspected to affect hear loss, such as gut bacteria for which they have conducted experiments with and without antibiotic treatment and found no difference.
A few additional results worth noting from the paper:
⋄ Female mice were experimented with first. Those fed the fish oil HFD exhibited patches of non-scarring, complete loss of hair shafts accounting for over 20% of the skin area. Then, similar was observed with male mice ... although at a reduced rate compared with female mice.
Figure 1:Female mice Figure S1:Male mice
⋄ PA [16:0 palmitic acid] was predominantly accumulated in epididymal fat, whereas DPA [docosapentaenoic acid] was mainly enriched in subcutaneous fat (Figure 4A), suggesting a specific skin distribution pattern of n-3 FAs.
Figure 4A
⋄ Compared with mice treated with vehicle PBS [phosphate-buffered saline[ control, mice treated with anti-TNF-a antibody successfully recovered from fish oil HFD-induced hair loss (Figures 3K and 3L).
Figures 3K and 3L