burtlancast
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https://en.wikipedia.org/wiki/Perchlorate
"Perchlorate is a potent competitive inhibitor of the thyroid sodium-iodide symporter.[48] Thus, it has been used to treat hyperthyroidism since the 1950s.[49] At very high doses (70,000–300,000 ppb) the administration of potassium perchlorate was considered the standard of care in the United States, and remains the approved pharmacologic intervention for many countries.
In large amounts perchlorate interferes with iodine uptake into the thyroid gland.
in January 2008, California's Department of Toxic Substances Control stated that perchlorate is becoming a serious threat to human health and water resources.
A study involving healthy adult volunteers determined that at levels above 0.007 milligrams per kilogram per day (mg/(kg·d)), perchlorate can temporarily inhibit the thyroid gland's ability to absorb iodine from the bloodstream ("iodide uptake inhibition", thus perchlorate is a known goitrogen).[55] The EPA converted this dose into a reference dose of 0.0007 mg/(kg·d) by dividing this level by the standard intraspecies uncertainty factor of 10. The agency then calculated a "drinking water equivalent level" of 24.5 ppb by assuming a person weighs 70 kilograms (154 pounds) and consumes 2 liters (68 ounces) of drinking water per day over a lifetime.[56]"
At a 2013 presentation of a previously unpublished study, it was suggested that environmental exposure to perchlorate in pregnant women with hypothyroidism may be associated with significant risk of low IQ in their children.[60]
In February 2008, U.S. Food and Drug Administration said that U.S. toddlers on average are being exposed to more than half of the U.S. EPA's safe dose from food alone.[65] In March 2009, a Centers for Disease Control study found 15 brands of infant formula contaminated with perchlorate. Combined with existing perchlorate drinking water contamination, infants could be at risk for exposure to perchlorate above the levels considered safe by E.P.A.[66]
"Perchlorate is a potent competitive inhibitor of the thyroid sodium-iodide symporter.[48] Thus, it has been used to treat hyperthyroidism since the 1950s.[49] At very high doses (70,000–300,000 ppb) the administration of potassium perchlorate was considered the standard of care in the United States, and remains the approved pharmacologic intervention for many countries.
In large amounts perchlorate interferes with iodine uptake into the thyroid gland.
in January 2008, California's Department of Toxic Substances Control stated that perchlorate is becoming a serious threat to human health and water resources.
A study involving healthy adult volunteers determined that at levels above 0.007 milligrams per kilogram per day (mg/(kg·d)), perchlorate can temporarily inhibit the thyroid gland's ability to absorb iodine from the bloodstream ("iodide uptake inhibition", thus perchlorate is a known goitrogen).[55] The EPA converted this dose into a reference dose of 0.0007 mg/(kg·d) by dividing this level by the standard intraspecies uncertainty factor of 10. The agency then calculated a "drinking water equivalent level" of 24.5 ppb by assuming a person weighs 70 kilograms (154 pounds) and consumes 2 liters (68 ounces) of drinking water per day over a lifetime.[56]"
At a 2013 presentation of a previously unpublished study, it was suggested that environmental exposure to perchlorate in pregnant women with hypothyroidism may be associated with significant risk of low IQ in their children.[60]
In February 2008, U.S. Food and Drug Administration said that U.S. toddlers on average are being exposed to more than half of the U.S. EPA's safe dose from food alone.[65] In March 2009, a Centers for Disease Control study found 15 brands of infant formula contaminated with perchlorate. Combined with existing perchlorate drinking water contamination, infants could be at risk for exposure to perchlorate above the levels considered safe by E.P.A.[66]