Milky said:https://raypeatforum.com/forums/posts/98053/ Two more questions haidut! (thanks in advance)
1) Maybe I'm just missing it, but can you clarify if the DMSO being used in IdeaLabs supplements is diluted with distilled water, etc? Or is it just the hormones mixed with 80% DMSO and 20% ethanol? I read elsewhere that DMSO is often diluted with water in different concentrations to help with skin irritation/itching in topical applications.
2) Can we talk a bit more about the "potentiating effect" of DMSO on steroid hormones? If it somehow increases their effectiveness, could it be said to do so in any measureable way? For instance, 5mg each of preg/DHEA in Pansterone administered with DMSO as a carrier not only has near 100% absorption, but has some factorial increase in effectiveness (2x, 3x, etc.) compared to oil or some other carrier. I guess I'm wondering about what the actual mechanism is for how DMSO might increase the effectiveness of the steroids.
The Pansterone supplement is dissolved in 80% DMSO and 20% ethanol. No water in it.
As far as DMSO potentiating the effects of steroids - the one study I saw on that long time ago said that this is due to DMSO increasing uptake of steroids into the cell. Officially, it is said that DMSO changes the permeability of the cell membrane. The tests included at least 10 hormones, including thyroid. It was shown that after treatment with DMSO, steroid uptake into the cell increased 3-5 fold, especially thyroid hormone, testosterone, and progesterone. So, this would mean 5mg DHEA in DMSO being equivalent to 15mg - 20mg without DMSO but also WITHOUT the estrogenic effects of DHEA in high doses. Unfortunately, I don't more since the study was quite old and I have not seen any new ones on that issue except showing that topical administration of steroids in DMSO rivals administration of much higher doses used orally or even IV. So, the potentiating effect seems to be there even though not much is known about it.
Btw, this gives an idea of dissolving thyroid hormone in DMSO/ethanol and using topically for a much more pronounced effect. I would love to release a supplement like that but unfortunately thyroid hormone is a controlled substance in the US.
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