Methylene Blue

jyb

Member
Joined
Nov 9, 2012
Messages
2,783
Location
UK
I wouldn't mind an experiment but I've only seen some MB for fish tanks (I worry about the purity) or for DNA testing (very expensive).
 
Joined
Nov 26, 2013
Messages
7,370
kiran said:
Such_Saturation said:
For some reason cyproheptadine can't be taken with monoamine oxidase inhibitors.

http://www.webmd.com/drugs/2/drug-8879/ ... rtype-drug

How the interaction occurs:
Monoamine oxidase inhibitors (MAOIs) may increase the effects of your antihistamine.

What might happen:
Your blood pressure may drop dangerously low.

Then I guess people should avoid cyproheptadine with this stuff before anything bad happens.

The Thorne combo only has 1mg MK4 every fifteen drops, so you're better off with the Life Extension product at that point.

The fact that vitamin A would pose the same dangers as PUFA seems odd to me, since in plants carotenoids are used to <<protect plant tissues by helping to absorb the energy from singlet oxygen, an excited form of the oxygen molecule O2 which is formed during photosynthesis>> and <<they protect chlorophyll from photodamage.>> [http://en.wikipedia.org/wiki/Carotene] [http://en.wikipedia.org/wiki/Carotenoid]
 

haidut

Member
Forum Supporter
Joined
Mar 18, 2013
Messages
19,798
Location
USA / Europe
Such_Saturation said:
kiran said:
Such_Saturation said:
For some reason cyproheptadine can't be taken with monoamine oxidase inhibitors.

http://www.webmd.com/drugs/2/drug-8879/ ... rtype-drug

How the interaction occurs:
Monoamine oxidase inhibitors (MAOIs) may increase the effects of your antihistamine.

What might happen:
Your blood pressure may drop dangerously low.

Then I guess people should avoid cyproheptadine with this stuff before anything bad happens.

The Thorne combo only has 1mg MK4 every fifteen drops, so you're better off with the Life Extension product at that point.

The fact that vitamin A would pose the same dangers as PUFA seems odd to me, since in plants carotenoids are used to <<protect plant tissues by helping to absorb the energy from singlet oxygen, an excited form of the oxygen molecule O2 which is formed during photosynthesis>> and <<they protect chlorophyll from photodamage.>> [http://en.wikipedia.org/wiki/Carotene] [http://en.wikipedia.org/wiki/Carotenoid]

I would not say it poses the same danger as PUFA, but it can suppress metabolism (conversion of T4 into T3) in higher doses if not taken with adequate vitamin E (100 IU vitamin E per every 100,000 IU of vitamin A). Ray has said vitamin A can be very anti-thyroid if not controlled properly, and also very pro-thyroid if used properly.
 
Joined
Nov 26, 2013
Messages
7,370
haidut said:
I would not say it poses the same danger as PUFA, but it can suppress metabolism (conversion of T4 into T3) in higher doses if not taken with adequate vitamin E (100 IU vitamin E per every 100,000 IU of vitamin A). Ray has said vitamin A can be very anti-thyroid if not controlled properly, and also very pro-thyroid if used properly.

Additionally, vitamin E enhances carotene conversion in the intestine. It is all very interesting.
 

charlie

Admin
The Law & Order Admin
Joined
Jan 4, 2012
Messages
14,363
Location
USA

charlie

Admin
The Law & Order Admin
Joined
Jan 4, 2012
Messages
14,363
Location
USA
Seems like my pupils have been dialated more then usual. Gonna hold off methylene blue and see if there is a change. I noticed that one of the symptoms of serotonin syndrome is dialated pupils. Not taking anything else that would add to that so not sure whats up. Oh and it seems like my vision might be a little bit cloudy on the peripheral.
 

charlie

Admin
The Law & Order Admin
Joined
Jan 4, 2012
Messages
14,363
Location
USA
Greg says said:
What about taking MB with Tianeptine? I started taking MB and stopped after a few days as I noticed when I moved my eyes from left to right, right to left, it really jolted. I experienced this when I used to take SSRIs.

Bump for answer.
 

charlie

Admin
The Law & Order Admin
Joined
Jan 4, 2012
Messages
14,363
Location
USA
Methylene blue is giving me blurred vision, and dry eyes. I have stopped so hopefully that will go away.
 
OP
M

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
Charlie said:
Methylene blue is giving me blurred vision, and dry eyes. I have stopped so hopefully that will go away.

Interesting, Charlie. I wonder why it's doing that.
 

Gl;itch.e

Member
Joined
Apr 12, 2014
Messages
732
Age
41
Location
New Zealand
Does anyone have any experience with using methylene blue to fight a fungal or viral infection?
 

artemis

Member
Joined
Dec 19, 2014
Messages
196
That was my main reason for trying it. I have not been real consistent with it, though. Have also added it to my bathwater about 5 or 6 times in the past few weeks. Looks so cool!

The fungal issue is definitely improving (could be due to many other things, too)

Still trying to work out whether the psychological effects are placebo or not. They are very subtle, for me, and feel a lot like the effects from caffeine, thyroid, etc.

But it's all good so far -- never anything undesirable.
 

Gl;itch.e

Member
Joined
Apr 12, 2014
Messages
732
Age
41
Location
New Zealand
artemis said:
That was my main reason for trying it. I have not been real consistent with it, though. Have also added it to my bathwater about 5 or 6 times in the past few weeks. Looks so cool!

The fungal issue is definitely improving (could be due to many other things, too)

Still trying to work out whether the psychological effects are placebo or not. They are very subtle, for me, and feel a lot like the effects from caffeine, thyroid, etc.

But it's all good so far -- never anything undesirable.
Are you using it topically for the fungal issue or just through normal supplementation orally?
 
OP
M

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
:). This is kind of funny. I asked doc p about my herniated cervical disc and cervical spondylosis. So he wrote back and said that it happens with low thyroid and an imbalance of DHEA to cortisol. He said aspirin and pregnenolone might help. This was the reference he included:

Pain. 2010 Apr;149(1):124-9.
A randomized placebo-controlled trial of intradiscal methylene blue injection for the treatment of chronic discogenic low back pain.
Peng B 1, Pang X, Wu Y, Zhao C, Song X.
A preliminary report of clinical study revealed that chronic discogenic low back pain could be treated by intradiscal methylene blue (MB) injection. We investigated the effect of intradiscal MB injection for the treatment of chronic discogenic low back pain in a randomized placebo-controlled trial. We recruited 136 patients who were found potentially eligible after clinical examination and 72 became eligible after discography. All the patients had discogenic low back pain lasting longer than 6 months, with no comorbidity. Thirty-six were allocated to intradiscal MB injection and 36 to placebo treatment. The principal criteria to judge the effectiveness included alleviation of pain, assessed by a 101-point numerical rating scale (NRS-101), and improvement in disability, as assessed with the Oswestry Disability Index (ODI) for functional recovery. At the 24-month follow-up, both the groups differed substantially with respect to the primary outcomes. The patients in MB injection group showed a mean reduction in pain measured by NRS of 52.50, a mean reduction in Oswestry disability scores of 35.58, and satisfaction rates of 91.6%, compared with 0.70%, 1.68%, and 14.3%, respectively, in placebo treatment group (p<0.001, p<0.001, and p<0.001, respectively). No adverse effects or complications were found in the group of patients treated with intradiscal MB injection. The current clinical trial indicates that the injection of methylene blue into the painful disc is a safe, effective and minimally invasive method for the treatment of intractable and incapacitating discogenic low back pain.
Copyright 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
 

tara

Member
Joined
Mar 29, 2014
Messages
10,368
@messtafarian, your doctor looks like a keeper. :)
 

narouz

Member
Joined
Jul 22, 2012
Messages
4,429
messtafarian said:
:). This is kind of funny. I asked doc p about my herniated cervical disc and cervical spondylosis. So he wrote back and said that it happens with low thyroid and an imbalance of DHEA to cortisol. He said aspirin and pregnenolone might help. This was the reference he included:

Pain. 2010 Apr;149(1):124-9.
A randomized placebo-controlled trial of intradiscal methylene blue injection for the treatment of chronic discogenic low back pain.
Peng B 1, Pang X, Wu Y, Zhao C, Song X.
A preliminary report of clinical study revealed that chronic discogenic low back pain could be treated by intradiscal methylene blue (MB) injection. We investigated the effect of intradiscal MB injection for the treatment of chronic discogenic low back pain in a randomized placebo-controlled trial. We recruited 136 patients who were found potentially eligible after clinical examination and 72 became eligible after discography. All the patients had discogenic low back pain lasting longer than 6 months, with no comorbidity. Thirty-six were allocated to intradiscal MB injection and 36 to placebo treatment. The principal criteria to judge the effectiveness included alleviation of pain, assessed by a 101-point numerical rating scale (NRS-101), and improvement in disability, as assessed with the Oswestry Disability Index (ODI) for functional recovery. At the 24-month follow-up, both the groups differed substantially with respect to the primary outcomes. The patients in MB injection group showed a mean reduction in pain measured by NRS of 52.50, a mean reduction in Oswestry disability scores of 35.58, and satisfaction rates of 91.6%, compared with 0.70%, 1.68%, and 14.3%, respectively, in placebo treatment group (p<0.001, p<0.001, and p<0.001, respectively). No adverse effects or complications were found in the group of patients treated with intradiscal MB injection. The current clinical trial indicates that the injection of methylene blue into the painful disc is a safe, effective and minimally invasive method for the treatment of intractable and incapacitating discogenic low back pain.
Copyright 2010 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

Wow. Very interesting! Thank's mess.
(now where is that hypodermic needle and a mirror... :D )
 
OP
M

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
More:
Dr. Peat:

I am very interested in Methylene Blue, as are many people who follow your writing and radio broadcasts. I bought some but I was concerned about its effect on blood pressure since it seems to be a hypertensive agent; but while I was hesitating I also wondered about its effect on serotonin uptake. It's a reversible MAOI so should conserve serotonin as well as all other brain chemicals as I understand this sort of thing.

Do you think there is a special or less detrimental action from Methylene Blue on serotonin? Or do you think the benefits outweigh the risks?

From Dr. Peat:

I think the most important therapeutic effects are in the range of a tenth of a milligram to one milligram per day, and the doses that inhibit MAO are in the range of hundreds of milligrams. I don't recommend it for anything that can be corrected by diet, thyroid, aspirin, antihistamine, progesterone, etc.
 
OP
M

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
Narouz, if my neck wasn't so close to my brain I'd slap some right on top of the c5 vertebrae :)
 
OP
M

messtafarian

Member
Joined
Aug 18, 2013
Messages
814
Tara, funny thing is Dr Peat at this point is my *only* doctor. All those other people I pay to visit don't seem to know what they're talking about.
 

narouz

Member
Joined
Jul 22, 2012
Messages
4,429
messtafarian said:
Narouz, if my neck wasn't so close to my brain I'd slap some right on top of the c5 vertebrae :)

:lol:
Wonder how one finds a specialist who would inject us?
Great info from Dr P about the very low dose!
Charlie could've benefited from that a few days ago. :D
 

Similar threads

Back
Top Bottom