This study looked specifically at mianserin, but did compare it to other drugs (including cyproheptadine). The conclusion was that mianserin and cyproheptadine extend lifespan by up to 30% by mimicking the effects of caloric restriction. Interestingly, mianserin increases appetite just like cyproheptadine, which the authors state is what creates a psychological state that makes the organism believe they are in caloric restriction.
Unsurprisingly, a number of SSRI drugs caused decrease in lifespan, sometimes up to 80%!
I have attached the study and the supplemental info. The supplemental info has the full list of the drugs tested and their effects on lifespan. For a good example of Peat being right on serotonin take a look at cyproheptadine's effects on lifespan (+20%) and compare it to a drug like Sertraline (Zoloft, -80%) or Paroxetine (Paxil, -76%) :)
http://www.nature.com/nature/journal/v4 ... 05991.html
"...Four compounds increased lifespan by 20%-30%: mianserin, mirtazapine, methioteptin and cyproheptadine (Fig. 1 and Supplementary Table 1). In humans, all four compounds are antagonists of serotonin 2 (5-HT2) receptor and, to a variable extent, of certain other biogenic amine receptors."
Unsurprisingly, a number of SSRI drugs caused decrease in lifespan, sometimes up to 80%!
I have attached the study and the supplemental info. The supplemental info has the full list of the drugs tested and their effects on lifespan. For a good example of Peat being right on serotonin take a look at cyproheptadine's effects on lifespan (+20%) and compare it to a drug like Sertraline (Zoloft, -80%) or Paroxetine (Paxil, -76%) :)
http://www.nature.com/nature/journal/v4 ... 05991.html
"...Four compounds increased lifespan by 20%-30%: mianserin, mirtazapine, methioteptin and cyproheptadine (Fig. 1 and Supplementary Table 1). In humans, all four compounds are antagonists of serotonin 2 (5-HT2) receptor and, to a variable extent, of certain other biogenic amine receptors."