Zinc Reduces Nitric Oxide (NO) Levels In Humans

[haidut]

The dose was 100mg elemental zinc for 3 months. Zinc inhibited NO synthesis from arginine. Combined with magnesium, zinc could be a viable alternative to methylene blue - magnesium for getting NO out of the cell and thus restoring cytochrome C activity, and zinc inhibiting new NO synthesis.

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3882288/

 

[Wilfrid]

What about the Adenosyl-form of B12? And using large amount of it via the percutaneous route?

http://hy-ls.org/index.php/hyls/article ... 5-1-PB.pdf

In the past, Ray warned me about zinc supplementation.
He said that supplemental zinc could oxidize vitamins in the intestine.
For that reason, according to him, no more than 10mg of zinc ( either sulfate or gluconate) should be used and for a period of 10 days max.
Are you agree with him on this?

 

[haidut]

What about the Adenosyl-form of B12? And using large amount of it via the percutaneous route?

http://hy-ls.org/index.php/hyls/article ... 5-1-PB.pdf

In the past, Ray warned me about zinc supplementation.
He said that supplemental zinc could oxidize vitamins in the intestine.
For that reason, according to him, no more than 10mg of zinc ( either sulfate or gluconate) should be used and for a period of 10 days max.
Are you agree with him on this?

There are many substances that lower NO (niacinamide, aspirin, methylene blue), and they all have various safety profiles. I probably would not take anything long term, even B12. Ray is probably right about zinc but if you have high levels of NO the benefit of taking zinc could outweigh the risks. A safer supplement may be magnesium, which Ray does recommend on a daily basis. I posted a study about that in another thread.

 

[ddjd]

What about the Adenosyl-form of B12? And using large amount of it via the percutaneous route?

http://hy-ls.org/index.php/hyls/article ... 5-1-PB.pdf

In the past, Ray warned me about zinc supplementation.
He said that supplemental zinc could oxidize vitamins in the intestine.
For that reason, according to him, no more than 10mg of zinc ( either sulfate or gluconate) should be used and for a period of 10 days max.
Are you agree with him on this?

I think hydroxyb12 is better than adenob12 for lowering NO

 

[magnilo]

could someone point me towards why would reducing NO be desirable? im actually aiming at the opposite..

 

[Mauritio]

Selenium also inhibits NO !

Treatment with Se (10(-6) M) markedly inhibited endotoxin (0.1 microg ml(-1))-induced NO production in J774A.1 cells. Se induced an increased activity of GSH-Px in cells after 24 h of incubation, suggesting that the preventive effect of Se on NO production in endotoxemia is due to the induction of Se-GSH-Px activity. However, Se did not affect endotoxin-induced cytotoxicity in J774A.1 cells. These findings suggested that the oxidative stress caused by endotoxin may be due, at least in part, to changes in Se regulation during endotoxemia.

Roles of selenium in endotoxin-induced lipid peroxidation in the rats liver and in nitric oxide production in J774A.1 cells. - PubMed - NCBI