X-rays Reveal The Important Role Of Copper In Parkinson’s Disease

Douglas Ek

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Dunno if theres a correlation but i know melanin is dependent on copper. The dopamine producing region substantia nigra in the basal ganglia of the brain (the area affected mostly in parkinsons disease) also containt neuromelanin cells that control the dopamine release (if it has melanin the in probably has copper). This area is also the most iron rich area of the brain. Studies have shown both cell death and symptoms of parkinson in people with to much iron in this area as people with lowered iron also show symptons restless legs and inhibited dopamine signaling. So iron seem essential to the dopaminergic function of the brain but to much is linked to cell death of the dopamine neurons. Copper has many ways to protect the body from iron excess. It helps keep iron out of depositing in the wrong places and transporting iron around the body to the right places through ceruloplasmin aswell protectin from oxidative stress caused by iron through the powerful SOD antioxidant system. Just another study proving the importance of copper regulation.

X-rays reveal the important role of copper in Parkinson’s disease

Another study also showed vitamin D protected these neurons aswell and that vitamin A was toxic Evaluation of the effects of vitamin A supplementation on adult rat substantia nigra and striatum redox and bioenergetic states: mitochondrial impair... - PubMed - NCBI
The rat doses was 1000-9000 IU vitamin-A. Dunno if they already converted that to human equiv but might be super high dosage
 
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lampofred

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Iron's Dangers

Copper is "necessary for the normal functioning of certain nerve cells (substantia nigra) whose degeneration is involved in Parkinson's disease."
 

Soren

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The rat doses was 1000-9000 IU vitamin-A. Dunno if they already converted that to human equiv but might be super high dosage

If that is the actual dose they gave the rat and not the human equivalent then it is a super high dose for something so small and I would not be surprised if it was shown to be toxic.
 

Douglas Ek

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If that is the actual dose they gave the rat and not the human equivalent then it is a super high dose for something so small and I would not be surprised if it was shown to be toxic.

Exactly what i thought
 

Douglas Ek

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Another interesting study mentioning that both vitamin C and E in combination and separate protect against RLS syndrome in hemodialysis patients. This is probably because of vitamin C and E antioxidant protection of irons oxidative stress that in overload would cause dopaminergic cell death. So all though iron can treat RLS symptoms by boosting dopamine function not getting enough protective vitamins like C and E would actually worsen the symptoms

Efficacy of vitamins C, E, and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, plac... - PubMed - NCBI

Efficacy of vitamins C, E, and their combination for treatment of restless legs syndrome in hemodialysis patients: a randomized, double-blind, placebo-controlled trial.
 
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