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Did you consume 1:1 with magnesium and with associated vitamins and minerals, like vitamin D3 and vitamin K2 MK-4?It doesnt a good idea for suffer from hairloss. calsification is one reason. when i consume lots of calsium resources, my hairloss worsened. Scalp Massage elasticity decrease.
@haidut - I know this is an old thread, but it's the only one in the forum that mentions Von Hippel Lindau - a protein that is malfunctioning in my body.This is certainly only one reason, but given how important for metabolism it is I thought it is worth mentioning. Calcium activates the enzyme pyruvate dehydrogenase (PDH), which takes the pyruvate produced by glycolysis, converts it to Acetyl-Co-A and thus starts the Krebs cycle. Calcium also seems to activate the other enzymes participating in the Krebs cycle.
Without properly functioning Krebs, cells will be stuck in glycolysis with excess pyruvate production. The excess pyruvate will get converted into lactate by the enzyme LDH, thus exhibiting the Warburg effect.
Finally, the proper functioning of the Krebs cycle and synthesis of its intermediate metabolites fumarate and succinate seems to restrain the enzyme HIF, which is so important in human pathology and especially cancer.
Citric acid cycle - Wikipedia
"...Calcium is used as a regulator. Mitochondrial matrix calcium levels can reach the tens of micromolar levels during cellular activation.[27] It activates pyruvate dehydrogenase phosphatase which in turn activates the pyruvate dehydrogenase complex. Calcium also activates isocitrate dehydrogenase and α-ketoglutarate dehydrogenase.[28] This increases the reaction rate of many of the steps in the cycle, and therefore increases flux throughout the pathway."
"...Recent work has demonstrated an important link between intermediates of the citric acid cycle and the regulation of hypoxia-inducible factors (HIF). HIF plays a role in the regulation of oxygen homeostasis, and is a transcription factor that targets angiogenesis, vascular remodeling, glucose utilization, iron transport and apoptosis. HIF is synthesized consititutively, and hydroxylation of at least one of two critical proline residues mediates their interaction with the von Hippel Lindau E3 ubiquitin ligase complex, which targets them for rapid degradation. This reaction is catalysed by prolyl 4-hydroxylases. Fumarate and succinate have been identified as potent inhibitors of prolyl hydroxylases, thus leading to the stabilisation of HIF."
@haidut - I know this is an old thread, but it's the only one in the forum that mentions Von Hippel Lindau - a protein that is malfunctioning in my body.
Do you think adding dietary Fumarate and Succinate would help in compensating for what the faulty Von Hippel Lindau protein fails to do?
For that condition, I would try a few mg methylene blue in combination with 10mg-20mg FAD (activated vitamin B2) and add 200mg-300mg succinate.
Calcium increases serotonin.
That doesn't make sense.I think in a good way, like Vitamin D, by reducing stress. Not in a degenerative way like estrogen
That doesn't make sense.
Where did you get that from? High serotonin is bad, there is no good high serotoninThings that lower cortisol raise serotonin. Serotonin rises when metabolism is slowed. But things like PUFA raise both cortisol and serotonin at the same time. That's how you know it's a degenerative rise in serotonin and not just a rise in serotonin because you are turning off a stress-driven increase in metabolism.
That's my guess.
Where did you get that from? High serotonin is bad, there is no good high serotonin
So you don't believe that you can have both low cortisol and low serotonin? A healthy organism should have low cortisol, low serotonin, and high dopamine / T3 / testosterone / etc. I can't think of anything serotonin is actually useful for, except for getting fat, mental disorders, metabolic syndrome, etc etc...
Source that sleeping raises serotonin? I would think it would drop serotonin as more serotonin would get converted into melatonin.High CO2/thyroid, no stress = low cortisol, low serotonin
High PUFA, estrogen, very unhealthy person = both high cortisol and high serotonin
But in between these two, you can do things that shift the balance between cortisol and serotonin. For example, sleeping raises serotonin but decreases cortisol. But obviously sleeping is not bad for you. I think calcium and Vitamin D act like sleep, they increase serotonin but only because they reduce stress driven metabolism and lower cortisol. Whereas in contrast, something degenerative like PUFA will raise serotonin and cortisol at the same time.
Source that sleeping raises serotonin? I would think it would drop serotonin as more serotonin would get converted into melatonin.
That's oversleeping, not sleep in general. All of this just sounds like conjecture, unless you have some study where blood serotonin levels go up during sleep I don't think your way of thinking makes sense.Dr. Peat's newsletter "Thought and energy, mood and metabolism" which says oversleeping shifts the stress hormone balance to serotonin.
Plus if you google the effect of sleep on prolactin, you'll find that falling asleep pretty instantly raises prolactin (and waking up decreases it). Prolactin is a very good marker for serotonin activity (learned that from Haidut)
That's oversleeping, not sleep in general. All of this just sounds like conjecture, unless you have some study where blood serotonin levels go up during sleep I don't think your way of thinking makes sense.
Ok, then how would you explain the studies that show that even a 15 minute daytime nap causes a large spike in prolactin, which instantly goes back down after waking up? But I do agree with what you're saying about how oversleeping could actually be a sign of excess serotonin. This is torpor/hibernation and not real sleep, and this is probably the sleep that most people over the age of 20 get, unfortunately. Maybe an explanation could be that deep slow wave sleep doesn't raise serotonin, but torpor/hibernation does.
Also a reason why you feel so bad when you don't get enough sleep might be high nitric oxide. Dr. Peat said sleep lowers nitric oxide. It probably also means you are in torpor, because slow wave sleep is very refreshing even if you get only small amounts of it.