Why is there an omega 3 "deficiency" in autistic children?

Ella

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StressedMom said:
post 110804 He obviously didn't tell me anything about curing autism, but suggested milk, cheese, eggs, shellfish, OJ, and cooked mushrooms for the diet and thyroid and pregnenolone as supplements.
He suggested high protein, mineral and cholesterol rich foods; precisely any rapidly developing young human requires along with thyroid to increase metabolism.
Why the pregnenolone?

The following is from Dr Bradshaw's website

Then you are in the 20% or so of children with low cholesterol. Since ALL steroid molecules are built from cholesterol it follows that the resultant sex steroids or their precursors (DHEA) would be low. And as you can see on the steroid pathway chart on the blog – cortisol also comes from cholesterol. There are two options for therapy: 1) supplemental or increased dietary cholesterol, and 2) supplemental pregnenolone. Going back to the chart for a moment you can see pregnenolone comes after cholesterol and before cortisol or DHEA. Since most children I see are allergic to eggs it is hard to get dietary cholesterol adequately supplemented. I often use pregnenolone in those cases. You also want to make sure fats are being absorbed. I see fat malabsorption in a significant population of children. Bile salt deficiency would follow from cholesterol deficiency as well. Here is the bile salt pathway – derived from cholesterol as you can see. So we get into a vicious cycle of poor absorption of fat – low cholesterol and then worse absorption of fat. Cannot put pictures in responses so here is the link. http://www.jlr.org/content/50/Supplement/S120.full

Bradshaw, continues to explain why pregnenolone is useful in these children.
"Actually DHEA can never balance cortisol. Cortisol is derived from pregnenolone via progesterone and DHEA is derived from pregenolone but down a different path via 17 hydroxypregnenolone. Study that steroid pathway on the blog and I think you will see why correcting hormones requires either Pregnenolone or Cholesterol.
Why mushrooms?
Lanosterol metabolism may be part of a global cellular response to stress. Low levels of lanosterol has been found in Alzheimer's disease and in fibroblasts challened by virus infection.
Exogenous lanosterol leads to mild uncoupling of mitachondria in dopaminergic and glutamatergtic neurons with no detectable impact on ATP.
Uncoupling reduces superoxide species in neuronal survival as oxidative stress is the primary cause of death. Lanosterol is a precursor for cholesterol biosythnesis and acts as a survival factor for dopaminergic neurons, regulates mitochondrial function and autophagy.
I am glad you were able to get onto Peat and he responded in offering you some guidance. Prehaps, not what you were expecting because food is kinda boring but fortunately nutritious food, is exactly what our cells need to generate their magic.
Best,
 
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StrongMom

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Ella said:
post 111104
StressedMom said:
post 110804 He obviously didn't tell me anything about curing autism, but suggested milk, cheese, eggs, shellfish, OJ, and cooked mushrooms for the diet and thyroid and pregnenolone as supplements.
He suggested high protein, mineral and cholesterol rich foods; precisely any rapidly developing young human requires along with thyroid to increase metabolism.
Why the pregnenolone?

The following is from Dr Bradshaw's website

Then you are in the 20% or so of children with low cholesterol. Since ALL steroid molecules are built from cholesterol it follows that the resultant sex steroids or their precursors (DHEA) would be low. And as you can see on the steroid pathway chart on the blog – cortisol also comes from cholesterol. There are two options for therapy: 1) supplemental or increased dietary cholesterol, and 2) supplemental pregnenolone. Going back to the chart for a moment you can see pregnenolone comes after cholesterol and before cortisol or DHEA. Since most children I see are allergic to eggs it is hard to get dietary cholesterol adequately supplemented. I often use pregnenolone in those cases. You also want to make sure fats are being absorbed. I see fat malabsorption in a significant population of children. Bile salt deficiency would follow from cholesterol deficiency as well. Here is the bile salt pathway – derived from cholesterol as you can see. So we get into a vicious cycle of poor absorption of fat – low cholesterol and then worse absorption of fat. Cannot put pictures in responses so here is the link. http://www.jlr.org/content/50/Supplement/S120.full

Bradshaw, continues to explain why pregnenolone is useful in these children.
"Actually DHEA can never balance cortisol. Cortisol is derived from pregnenolone via progesterone and DHEA is derived from pregenolone but down a different path via 17 hydroxypregnenolone. Study that steroid pathway on the blog and I think you will see why correcting hormones requires either Pregnenolone or Cholesterol.
Why mushrooms?
Lanosterol metabolism may be part of a global cellular response to stress. Low levels of lanosterol has been found in Alzheimer's disease and in fibroblasts challened by virus infection.
Exogenous lanosterol leads to mild uncoupling of mitachondria in dopaminergic and glutamatergtic neurons with no detectable impact on ATP.
Uncoupling reduces superoxide species in neuronal survival as oxidative stress is the primary cause of death. Lanosterol is a precursor for cholesterol biosythnesis and acts as a survival factor for dopaminergic neurons, regulates mitochondrial function and autophagy.
I am glad you were able to get onto Peat and he responded in offering you some guidance. Prehaps, not what you were expecting because food is kinda boring but fortunately nutritious food, is exactly what our cells need to generate their magic.
Best,

Thanks again Ella for letting me know of these research. I have a lot to learn.
 
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burtlancast

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I spent five years with one of his protege here in Australia trying to understand the methodology they use in not only diagnosing mercury toxicity but also eliminating mercury from the body, so I am well aware of Haley's work. I remain unconvinced.

How so ?
Haley is a world specialist on mercury toxicity; he has invented a new synthetic chelator with high specificity for heavy metals and low toxicity. Many doctors have used it to treat successfully autistic children affected with a high mercury load.
Then the FDA came to shut his research down.

I would like to remind everyone that a high mercury load paralyses the detoxifying system, making the sufferer accumulate even more heavy metals ( lead, arsenic, ....) in a vicious circle.
Mercury chelation works.
Just stay away from naturopathic doctors advertising chelation with chlorella, vit c, coriander, ....( none of which work)


Peat may not have directly elucidated the nutritional requirements specific for autism, but you need to read between the lines to understand the nuances.

I'm all for Ray.
But you need to evaluate what evidence he's offering you; has he worked with autistic children with a high mercury load ? Has he cured them ? By all means, one should try his dietary approaches. But if it doesn't bring results, then one has to look for other solutions.

I've mentioned Haley because he did all these things, and he did obtain results.

As far as understanding the nuances, i remember Ray mentioning in one of his interviews that having a higher load of mercury isn't necessarily incompatible with good health ( he was taking the example of newborns whose mothers ate a lot of fish during pregnancy, and whose children showed a higher intelligence than normal, even though they had higher mercury loads).

I leave it to you to appreciate the correctness of this assertion ( ).
 

michael94

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How so ?
Haley is a world specialist on mercury toxicity; he has invented a new synthetic chelator with high specificity for heavy metals and low toxicity. Many doctors have used it to treat successfully autistic children affected with a high mercury load.
Then the FDA came to shut his research down.

I would like to remind everyone that a high mercury load paralyses the detoxifying system, making the sufferer accumulate even more heavy metals ( lead, arsenic, ....) in a vicious circle.
Mercury chelation works.
Just stay away from naturopathic doctors advertising chelation with chlorella, vit c, coriander, ....( none of which work)




I'm all for Ray.
But you need to evaluate what evidence he's offering you; has he worked with autistic children with a high mercury load ? Has he cured them ? By all means, one should try his dietary approaches. But if it doesn't bring results, then one has to look for other solutions.

I've mentioned Haley because he did all these things, and he did obtain results.

As far as understanding the nuances, i remember Ray mentioning in one of his interviews that having a higher load of mercury isn't necessarily incompatible with good health ( he was taking the example of newborns whose mothers ate a lot of fish during pregnancy, and whose children showed a higher intelligence than normal, even though they had higher mercury loads).

I leave it to you to appreciate the correctness of this assertion ( ).


Interesting. I remember reading about that guy and the articles made him out to be a crackpot poisoning people. What do you know of this situation and his product?
 

burtlancast

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