Why Are Gelatin And Glycine Recommended If Glycine Increases Serotonin Levels?

mrchibbs

Member
Joined
Nov 22, 2017
Messages
2,374
Location
Atlantis

Hgreen56

Member
Thread starter
Joined
Apr 8, 2020
Messages
522

mrchibbs

Member
Joined
Nov 22, 2017
Messages
2,374
Location
Atlantis

I don't know what is going on in that study, maybe somebody else can comment on it.

What I know is that on a physiological level, serotonin is produced from tryptophan.
Gelatin contains no tryptophan at all, therefore it can't lead to more serotonin.

Dietary glycine hasn't been as useful as gelatin itself for many people.
 

johnwester130

Member
Joined
Aug 6, 2015
Messages
2,823

mrchibbs

Member
Joined
Nov 22, 2017
Messages
2,374
Location
Atlantis
I believe Haidut has mentioned that brain serotonin is primarily driven by tryptophan intake/conversion to serotonin while peripheral serotonin is primarily driven by endotoxin/gut bacteria.

Interesting distinction
 

Terma

Member
Joined
May 8, 2017
Messages
1,062
Specifically:
Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats.
Bannai M1, Kawai N, Nagao K, Nakano S, Matsuzawa D, Shimizu E.
Author information
Abstract

AIM:
Glycine, one of the non-essential amino acids, has been reported to be effective in reducing negative symptoms of schizophrenia. Recently, we found that glycine improves subjective sleep quality in humans. The aim of this study was to investigate the effects of oral glycine administration on endogenous 5-hydroxytryptamine (5-HT) and dopamine in the prefrontal cortex (PFC) of living rats.

METHODS:
Microdialysis probes were inserted stereotaxically into the rat prefrontal cortex. Cortical levels of 5-HT and dopamine were measured following oral administration of 1 or 2 g/kg glycine, 2 g/kg d-serine, or 2 g/kg L-serine.

RESULTS:
Both glycine and d-serine significantly increased extracellular 5-HT levels for 10 min, whereas dopamine levels remained unchanged. L-serine, in contrast, had no significant effects on 5-HT levels.

CONCLUSIONS:
It is possible that the increase in 5-HT in response to glycine and d-serine was mediated by N-methyl-D-aspartate receptors. The transient increase in 5-HT in the PFC might be associated with the alleviation of negative symptoms in patients with schizophrenia and the amelioration of sleep quality in patients with insomnia.
NMDA activation (assuming) at 2g/kg rat weight with no other added nutrients could be stressful and is not really anything new.

What's interesting is L-serine didn't do this even though it can produce glycine and I've been wondering to what degree it might/not activate NMDA receptors (suggesting it's safe for sleep).
 
Similar threads
Thread starter Title Forum Replies Date
R Gelatin vs pork crackle for glycine? Amino Acids 6
R Low-dose copper with glycine and proline or gelatin for collagen? Ask For Help or Advice 2
A Gelatin/Glycine In Ground Beef Meat, Organ Meat, Gelatin, Seafood 7
M Do You Feel A Difference From Taking Glycine Or Gelatin Or Aspirin? Ask For Help or Advice 5
_lppaiva Glycine As A Temporary Alternative To Gelatin, Since No Good Brands Are Available? Supplements, Pharmaceutical Drugs 29
olive Gelatin Enhances Non-gene Iron Uptake, Glycine Does Not Scientific Studies 3
cyclops Glycine Vs Powdered Gelatin Diet 45
P Gelatin Vs Glycine Diet 4
Peatit Gelatin/glycine timing Supplements 8
alexander101 Jello vs Gelatin (for glycine content) Gelatin 4
sunmountain Gelatin Vs Pure Glycine? Amino Acids 49
chris glycine gelatin question Gelatin 15
GreekDemiGod Haribo gummies as a Gelatin source? Diet 5
G IBS-D Cured With Gelatin? Digestion, Gut Flora 3
G Premature Ejaculation Cured With Gelatin? Male Issues 3
G Beef Gelatin Taste Is Disgusting Gelatin 1
L Reliable Gelatin Powders Digestion 3
lyfe Gelatin Creme Brulee - FINALLY A Gelatin Recipe I LOVE To Eat Recipes 13
lyfe Does Gelatin Need To Set Before Consumed? Gelatin 8
orewashin Why Would Gelatin Specifically Cause Me To Feel "wired"? Diet 4
wealthofwisdom Is Collagen As Good As Gelatin? Diet 15
wealthofwisdom Collagen Vs Gelatin? Diet 2
James Myatt Canned Gelatin Ask For Help or Advice 6
Pieter Stress, Coffee, Wellbutrin, Sleep And Gelatin Blood Sugar 2
Rosiemax14 Gelatin Danny Roddy 0
James Myatt Hydrolised Collagen/gelatin Allergic Response Ask For Help or Advice 3
D Anyone NOT Do Well While Taking Gelatin - What Reactins/Symptoms? Symptoms, Causes 19
B Nothing But 1% Milk, Juices, Salt, And Gelatin? Ask For Help or Advice 32
berk Is This A Good Gelatin Supplement? Supplements, Pharmaceutical Drugs 0
D Gelatin's "Recommended Dosages" Way, Way Too High And Gelatin 42
D Vitamin C As Catalyst For Gelatin Necessary? Gelatin 1
ecstatichamster Gelatin Smelled Like A Meat Rendering Plant - Threw It Away Gelatin 19
Hans Collagen/gelatin Aids In Muscle Growth And Fat Loss Blogs 7
N Protein Needs With Gelatin And Rice - Except For Tryptophan Protein 5
L How Infrequently Can You Eat Gelatin? Gelatin 0
W Link To Ray Peat Gelatin And Orange Juice Recipe? Gelatin 3
S Does Gelatin HAVE To Be In Hot Water/heat? Gelatin 4
W Best Brand Gelatin 2019? Gelatin 23
johnwester130 A Must Read Article On Gelatin Gelatin 1
Cirion Peat Is Right About Amino Acids / Gelatin Gelatin 61
C My Gelatin Testimonial So Far Gelatin 4
johnwester130 Don't Forget To Supplement Tryptophan If You Take Gelatin Gelatin 3
johnwester130 Does Anyone Know Which Hormones Are In Gelatin Gelatin 4
johnwester130 Has This Study About Gelatin And Hair Been Posted Before ? Hair & Nails 2
Inaut Gelatin+Vitamin C Shots Gelatin 6
J Gelatin Caused Nightmares And Poor Sleep? Gelatin 1
G Gelatin Gives Me A Headache Diet 8
K Collagen Or Gelatin Ask For Help or Advice 4
T Selling Great Lakes Bovine Gelatin Gelatin 11
D Chocolate, Coffee And Gelatin Candy Recipes 3

Similar threads

Top