Why Are Gelatin And Glycine Recommended If Glycine Increases Serotonin Levels?

mrchibbs

Member
Joined
Nov 22, 2017
Messages
3,135
Location
Atlantis

mrchibbs

Member
Joined
Nov 22, 2017
Messages
3,135
Location
Atlantis

I don't know what is going on in that study, maybe somebody else can comment on it.

What I know is that on a physiological level, serotonin is produced from tryptophan.
Gelatin contains no tryptophan at all, therefore it can't lead to more serotonin.

Dietary glycine hasn't been as useful as gelatin itself for many people.
 

mrchibbs

Member
Joined
Nov 22, 2017
Messages
3,135
Location
Atlantis
upload_2020-5-1_12-13-5.png




Gelatin, stress and longevity
 

mrchibbs

Member
Joined
Nov 22, 2017
Messages
3,135
Location
Atlantis
upload_2020-5-1_12-16-1.png
 

David PS

Member
Joined
Jan 5, 2016
Messages
14,675
Location
Dark side of the moon

johnwester130

Member
Joined
Aug 6, 2015
Messages
3,563

mrchibbs

Member
Joined
Nov 22, 2017
Messages
3,135
Location
Atlantis
I believe Haidut has mentioned that brain serotonin is primarily driven by tryptophan intake/conversion to serotonin while peripheral serotonin is primarily driven by endotoxin/gut bacteria.

Interesting distinction
 

Terma

Member
Joined
May 8, 2017
Messages
1,063
Specifically:
Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats.
Bannai M1, Kawai N, Nagao K, Nakano S, Matsuzawa D, Shimizu E.
Author information
Abstract

AIM:
Glycine, one of the non-essential amino acids, has been reported to be effective in reducing negative symptoms of schizophrenia. Recently, we found that glycine improves subjective sleep quality in humans. The aim of this study was to investigate the effects of oral glycine administration on endogenous 5-hydroxytryptamine (5-HT) and dopamine in the prefrontal cortex (PFC) of living rats.

METHODS:
Microdialysis probes were inserted stereotaxically into the rat prefrontal cortex. Cortical levels of 5-HT and dopamine were measured following oral administration of 1 or 2 g/kg glycine, 2 g/kg d-serine, or 2 g/kg L-serine.

RESULTS:
Both glycine and d-serine significantly increased extracellular 5-HT levels for 10 min, whereas dopamine levels remained unchanged. L-serine, in contrast, had no significant effects on 5-HT levels.

CONCLUSIONS:
It is possible that the increase in 5-HT in response to glycine and d-serine was mediated by N-methyl-D-aspartate receptors. The transient increase in 5-HT in the PFC might be associated with the alleviation of negative symptoms in patients with schizophrenia and the amelioration of sleep quality in patients with insomnia.
NMDA activation (assuming) at 2g/kg rat weight with no other added nutrients could be stressful and is not really anything new.

What's interesting is L-serine didn't do this even though it can produce glycine and I've been wondering to what degree it might/not activate NMDA receptors (suggesting it's safe for sleep).
 

VitoScaletta

Member
Joined
Feb 22, 2022
Messages
398
Location
Palestine
Specifically:

NMDA activation (assuming) at 2g/kg rat weight with no other added nutrients could be stressful and is not really anything new.

What's interesting is L-serine didn't do this even though it can produce glycine and I've been wondering to what degree it might/not activate NMDA receptors (suggesting it's safe for sleep).
Thank you.
Bro, you saved me from some concern haha.
 
EMF Mitigation - Flush Niacin - Big 5 Minerals

Similar threads

Back
Top Bottom