- Apr 8, 2020
according to this article
well i found this to:1) Not a scientific article
2) A confused psychologist who adheres to the medical dogma that serotonin is the ''good hormone''
3) Don't believe everything you read (see #1)
On balance, glycine and gelatin are much more positive than negative.
Read some of the information that Ray has posted. Here are some of his articles to begin your search for understanding.
Gelatin, stress, longevity
Tryptophan, serotonin, and aging
Adaptive substance, creative regeneration: Mainstream science, repression, and creativity
I believe Haidut has mentioned that brain serotonin is primarily driven by tryptophan intake/conversion to serotonin while peripheral serotonin is primarily driven by endotoxin/gut bacteria.
NMDA activation (assuming) at 2g/kg rat weight with no other added nutrients could be stressful and is not really anything new.Oral administration of glycine increases extracellular serotonin but not dopamine in the prefrontal cortex of rats.
Bannai M1, Kawai N, Nagao K, Nakano S, Matsuzawa D, Shimizu E.
Glycine, one of the non-essential amino acids, has been reported to be effective in reducing negative symptoms of schizophrenia. Recently, we found that glycine improves subjective sleep quality in humans. The aim of this study was to investigate the effects of oral glycine administration on endogenous 5-hydroxytryptamine (5-HT) and dopamine in the prefrontal cortex (PFC) of living rats.
Microdialysis probes were inserted stereotaxically into the rat prefrontal cortex. Cortical levels of 5-HT and dopamine were measured following oral administration of 1 or 2 g/kg glycine, 2 g/kg d-serine, or 2 g/kg L-serine.
Both glycine and d-serine significantly increased extracellular 5-HT levels for 10 min, whereas dopamine levels remained unchanged. L-serine, in contrast, had no significant effects on 5-HT levels.
It is possible that the increase in 5-HT in response to glycine and d-serine was mediated by N-methyl-D-aspartate receptors. The transient increase in 5-HT in the PFC might be associated with the alleviation of negative symptoms in patients with schizophrenia and the amelioration of sleep quality in patients with insomnia.
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