What would you do with these blood results?

[Callmestar]

I've had some great advice from people here on my other thread about dehydration and I continue to work on things taking on board some of the suggestions made. Frustratingly I've not seen much improvement and recent blood tests look as though certain things such as testosterone is decreasing. I'm at the point where I'm feeling so crap all the time and little progress through diet/supplements etc that I'm considering if TRT or similar might be worth a try in my situation. I will post my recent blood results below. If anyone has any advice on what they'd do with blood levels like this then I'd appreciate the advice.

Just to add, I was taking thyroxine 50mcg a day for a couple of months up until recently and also tried tyronene/T3 but didn't really feel any benefit. I can see from this recent test my TSH is relatively similar to where it's been for a while but is slowly creeping up so will likely try some thyroid again. Although at this point I'm really not sure what to do.

If anyone can work out whats going on with my hormones? My DHEA is always this high, way out of range, never sure why. Cholesterol is high and always seems to be no matter my weight. I am not in particularly bad shape.

 

[Callmestar]

Main symptoms are dehydration, frequent urination, dry mouth, fatigue.

Just attempted to do some light exercise; feel as though I'm on the very of passing out, body and heart have no capacity or energy to do anything more than lay around.

 

[JohnHafterson]

Interesting blood tests.

Could have a couple things going on but first glance low hanging fruit of lab tests here looks like based on low SHBG, high triglycerides, low HDL, and potentially moderately elevated ferritin. I think you probably have some insulin resistance going on.

How old are you how have SHBG, Triglycerides, HDL, ferritin been trending compare to previous threads.

Are you on any meds?

 

[Callmestar]

Interesting blood tests.

Could have a couple things going on but first glance low hanging fruit of lab tests here looks like based on low SHBG, high triglycerides, low HDL, and potentially moderately elevated ferritin. I think you probably have some insulin resistance going on.

How old are you how have SHBG, Triglycerides, HDL, ferritin been trending compare to previous threads.

Are you on any meds?

Thanks for your input. I'm 32. I've only had SHBG tested once before, it's come down from 20 to 15 in about 7 months. Cholesterol / Triglycerides remain around the same, consistently high. Although Triglycerides appear much higher in the results posted above probably because I was not fasted and had eaten just before. Here is my most comprehensive blood test results from January Chronic health problem (Dehydration) - Faint hope somebody here might have some ideas

And these are more recent results over the past few months:

Total prostate specific antigen level 0.5 ug/L [< 2.5]
Serum testosterone level 10.4 nmol/L [8.0 - 31.0]
Oestradiol < 62 pmol/L [< 159.0]
Prolactin 176 mu/L [< 700.0]
Urea and electrolytes
Serum sodium level 141 mmol/L [133.0 - 146.0]
Serum potassium level 4.2 mmol/L [3.5 - 5.3]
Serum creatinine level 94 umol/L [59.0 - 104.0]
eGFR using creatinine (CKD-EPI) per 1.73 square metres > 90 mL/min [> 60.0]
Urate 412 umol/L [200.0 - 430.0]
Serum TSH level 3.1 miu/L [0.2 - 5.5]
Serum free T4 level 16.4 pmol/L [10.0 - 24.5]

Serum dehydroepiandrosterone level 16.6 umol/L [2.2 - 15.2

For Supine patients:
(Supine)
Renin Reference Range 5.4 - 30.0 mU/L
Aldosterone Reference range 100 - 450 pmol/L
Plasma aldosterone level 408 pmol/L [100.0 - 800.0]
Plasma renin level 16.3 mu/L [5.4 - 60.0]
Plasma aldosterone:renin activity ratio 25 [< 80.0]

(Upright)
Plasma aldosterone:renin activity ratio 9 pmol/mIU [< 80]
Plasma renin level 42.6 mu/L [5.4 - 60]
Plasma aldosterone level 388 pmol/L [100 - 800]

Morning Cortisol 606nmol/L

Full blood count
Haemoglobin concentration 154 g/L [130.0 - 180.0]
Total white blood count 5.6 10*9/L [3.6 - 11.0]
Platelet count - observation 294 10*9/L [140.0 - 400.0]
Red blood cell count 4.96 10*12/L [4.5 - 6.5]
Haematocrit 0.450 [0.4 - 0.54]
Mean cell volume 90.6 fL [80.0 - 100.0]
Mean cell haemoglobin level 31.1 pg [27.0 - 32.0]
Neutrophil count 2.92 10*9/L [1.8 - 7.5]
Lymphocyte count 1.93 10*9/L [1.0 - 4.0]
Monocyte count - observation 0.52 10*9/L [0.2 - 0.8]
Eosinophil count - observation 0.18 10*9/L [0.1 - 0.4]
Basophil count 0.04 10*9/L [0.02 - 0.1]

I'm lost to be honest and things just seem to be gradually getting worse.

 

[Callmestar]

Interesting blood tests.

Could have a couple things going on but first glance low hanging fruit of lab tests here looks like based on low SHBG, high triglycerides, low HDL, and potentially moderately elevated ferritin. I think you probably have some insulin resistance going on.

How old are you how have SHBG, Triglycerides, HDL, ferritin been trending compare to previous threads.

Are you on any meds?

Sorry not sure if you edited your post. I didn't see the bit about the meds. No I'm not on any medication. I was taking some thyroxine up until recently under the suspicion I might be hypothyroid based on some of the advice given here. I didn't feel any benefit though so tapered off.

 

[mariantos]

Sorry not sure if you edited your post. I didn't see the bit about the meds. No I'm not on any medication. I was taking some thyroxine up until recently under the suspicion I might be hypothyroid based on some of the advice given here. I didn't feel any benefit though so tapered off.

Did you solve your prostate problem?
Has antibiotic treatment proved to be effective or are you still facing that situation?

 

[Callmestar]

Did you solve your prostate problem?
Has antibiotic treatment proved to be effective or are you still facing that situation?

The prostate problem remains. I tried a 2 week course of antibiotics but saw no improvement.

 

[mariantos]

The prostate problem remains. I tried a 2 week course of antibiotics but saw no improvement.

I see, I'm sorry to hear that. Let's hope there is a knowledgeable member to guide you properly based on your results!

 

[JohnHafterson]

Have read through your other thread.

You've been around the block with docs/endos/etc.

You've arrived at Diabetes Insipidus type status.

Thyroid-Adrenal-Hypothalamus-Pituitary - somewhere in there or leading to there.

Good to know you still have the fight and are on the hunt. Nothing wrong with shopping around for physicians while you piece together what works or doesn't work on your own.

See you're in UK. Are you able to access University or teaching hospitals which may have a better handle on rarer/unique conditions?

 

[Callmestar]

Have read through your other thread.

You've been around the block with docs/endos/etc.

You've arrived at Diabetes Insipidus type status.

Thyroid-Adrenal-Hypothalamus-Pituitary - somewhere in there or leading to there.

Good to know you still have the fight and are on the hunt. Nothing wrong with shopping around while you piece together what works or doesn't work on your own.

See you're in UK. Are you able to access University or teaching hospitals which may have a better handle on rarer/unique conditions?

Yes I've been to university hospitals. Seen supposedly the best Endocrinologists in the UK. I get better information from those on here than from any specialist. They literally have no idea or don't take enough time to try and work out what's going on.

Yep, Thyroid-Adrenal-Hypothalamus-Pituitary sounds about right, but is now somehow taking a toll on my sex hormones. Leaves me in a situation where I don't necessarily think low test is causing my symptoms and is more likely a result of my condition but I may well try TRT to see if it at least gives me some level of life and vitality or to keep things from declining further.

Did you have any further thoughts on the possible insulin resistance or is that not what it looks like after seeing more of my blood work?

 

[Hans]

I've had some great advice from people here on my other thread about dehydration and I continue to work on things taking on board some of the suggestions made. Frustratingly I've not seen much improvement and recent blood tests look as though certain things such as testosterone is decreasing. I'm at the point where I'm feeling so crap all the time and little progress through diet/supplements etc that I'm considering if TRT or similar might be worth a try in my situation. I will post my recent blood results below. If anyone has any advice on what they'd do with blood levels like this then I'd appreciate the advice.

Just to add, I was taking thyroxine 50mcg a day for a couple of months up until recently and also tried tyronene/T3 but didn't really feel any benefit. I can see from this recent test my TSH is relatively similar to where it's been for a while but is slowly creeping up so will likely try some thyroid again. Although at this point I'm really not sure what to do.

If anyone can work out whats going on with my hormones? My DHEA is always this high, way out of range, never sure why. Cholesterol is high and always seems to be no matter my weight. I am not in particularly bad shape.



View attachment 26397View attachment 26398View attachment 26399

Overactive adrenals mostly. Have you checked rT3 as well? It might be elevated, since despite fT3 being normal, cholesterol and trigs are still high.
What's your diet like?

 

[Cooper]

Main symptoms are dehydration, frequent urination, dry mouth, fatigue.

Just attempted to do some light exercise; feel as though I'm on the very of passing out, body and heart have no capacity or energy to do anything more than lay around.

Do you have any libido and sexual symptoms too? Or they feel the same? Did you use any kind of medication prior to your symptoms occurance timeline?

 

[Callmestar]

Overactive adrenals mostly. Have you checked rT3 as well? It might be elevated, since despite fT3 being normal, cholesterol and trigs are still high.
What's your diet like?

rT3 is one of few things I haven't had tested, I will get it done. If it is elevated, what would be the solution? Taking thyroid in high doses?

My diet was initially relatively low in calories, 2 meals a day, I had no hunger for anything more. Since the advice of those here a few months ago my calories have increased and I am eating around 2500-3000 calories mainly consisting of fruit, orange juice, milk, collagen, grass-fed beef, carrot salad, coconut oil, eggs, veg, rice, potato, some muscle meat here and there. I threw in some chocolate milk a month or so ago on the advice of someone here as I was still feeling completely depleted. I've been putting on quite a bit of fat since though so have cut back on the chocolate milk. The change of diet hasn't made me feel any better.

 

[Callmestar]

Do you have any libido and sexual symptoms too? Or they feel the same? Did you use any kind of medication prior to your symptoms occurance timeline?

No medication at all. My libido I think is pretty much the same, but maybe it's slightly lower and is hard to tell as I've been feeling like this for a few years. There's definitely not a massively noticeable difference to libido. General energy and wellbeing are awful, but libido no noticeable change.

 

[Hans]

rT3 is one of few things I haven't had tested, I will get it done. If it is elevated, what would be the solution? Taking thyroid in high doses?

My diet was initially relatively low in calories, 2 meals a day, I had no hunger for anything more. Since the advice of those here a few months ago my calories have increased and I am eating around 2500-3000 calories mainly consisting of fruit, orange juice, milk, collagen, grass-fed beef, carrot salad, coconut oil, eggs, veg, rice, potato, some muscle meat here and there. I threw in some chocolate milk a month or so ago on the advice of someone here as I was still feeling completely depleted. I've been putting on quite a bit of fat since though so have cut back on the chocolate milk. The change of diet hasn't made me feel any better.

If rT3 is high, then it would be best to stop all thyroid meds containing T4 and only use T3. This will help to bring rT3 back down.

Which supps are you using or have you used?

 

[tallglass13]

No medication at all. My libido I think is pretty much the same, but maybe it's slightly lower and is hard to tell as I've been feeling like this for a few years. There's definitely not a massively noticeable difference to libido. General energy and wellbeing are awful, but libido no noticeable change.

Thanks for labs. Interesting. May I ask how your head hair is doing?

 

[Callmestar]

Thanks for labs. Interesting. May I ask how your head hair is doing?

I have a full head of thick hair. You'd think it would have started to fall out with how crap I feel but seems genetically my family keep the hair on our heads. i.e my dad at 60 and my brother also have full heads of hair.

 

[Callmestar]

If rT3 is high, then it would be best to stop all thyroid meds containing T4 and only use T3. This will help to bring rT3 back down.

Which supps are you using or have you used?

It's a long list to be honest. For now I've come off most supplements other than some potassium and magnesium started recently as an experiment I'm trying from the advice of someone here. Previously I was taking, thiamine, b complex, Vit d, zinc, digestive enzymes GABA, NAC, Thyroid granular, I mean the list is endless of what I've tried but not one of them has made any difference. I've also taken thyroxine for a few weeks which made no difference, taken T3 on it's own which seems to occasionally give a subtle lift but the majority of the time I feel nothing from it.

 

[Callmestar]

I've spoken with a hormone replacement clinic here in the UK and they are recommending/offering TRT based on my results. What do you guys think?

I would have rather got things back on track more naturally but I'm getting nowhere and my quality of life has been awful for a few years now.

 

[JohnHafterson]

Regarding insulin resistance considered it due to low shbg, high triglycerides, low hdl NOT knowing that your test wasn't fasted. Viewing other labs triglycerides in better range. Also now knowing age 32 and given what else may be going on and serum insulin only slightly elevated with good a1c.

Personally think your thyroid issues are not the cause but are caused by whatever is going on.

Seems like early 1930's literature discusses Insipidus and thyroid coexisting and thyroid treatment exacerbating.

Interesting that when you exercise/sweat you notice some temporary improvement.

Could be you're influencing the body to use other mechanisms skin vs kidney to manage fluid and electrolyte levels swinging (hacking) things the other way temporarily.

I was going to recommend sauna but its sounds like you've been doing that.

Did you notice any temporary improvement with sauna similar to when you exercise/sweat?

Interesting the short or long-term water restriction as well temporarily kind of hacking comfort levels back a little.

The sugary beverages benefiting is interesting, insulin can help to retain fluids and works in concert with vasopressin to do so.

Though could be a temporary bump for metabolism and body being distracted by digestion/etc.

And you've tried treatment regimens targeting the nephrogenic form of Insipidus?