What T4:T3 ratio works best for you?

[Vileplume]

A thread for people to post experiences with various T4:T3 thyroid ratios.

I've taken cynoplus (4:1, 120:30) for over a year without much of an impact on temps, but now that I added cynomel and reduced my cynoplus, I'm seeing increases in temperature. My waking temp is now 97.0F (used to be 96.7), and I'm reaching 98.6F some afternoons.

My current T4:T3 ratio is 2:1, or 60:30mcg. This is just over 1.5 grains, I believe. It's been about one week on this dose, and I plan to increase by 1/2 grain next week, assuming my temps stay below Dr. Barnes' range.

If possible, please share:
-What ratio of t4:t3 works best for you
-What products you use (cynoplus, NDT, tyromix, etc.)
-What other doses you've tried (if any)
-How long you've been taking thyroid

 

[ecstatichamster]

3:1 seems to work best.

I’ve been doing this for years.

Cynoplus works best.

 

[Jessie]

Tyromix, which is 2:1 ratio. I've never actually used Cynoplus, even though most people seem to vouch for it. So I have no idea how I'd respond to a 3:1 ratio.

I know that 2:1 works well for me, and in the past, when I've used NDT, it did not work so well for me. NDT usually ranges from 4:1 to 5:1 from what I gather.

I've had a lot of "on and off" experiences with thyroid. So if you count all the times I used it, then several years. Successfully about a year now.

I'm more interested in hearing how people dose their product. Do you take the entire 1.5 grains at once, or do you spread it out?

 

[Vileplume]

I’m more interested in hearing how people dose their product. Do you take the entire 1.5 grains at once, or do you spread it out?

I break the cynoplus up into fourths, and I break the cynomel up into 8ths (3.1 mcg T3 each). Then I spread doses throughout the day.

If I wake up in the middle of the night, I take a little piece of T3 with some milk. During daytime, it looks like this:

7 am: 3.1 mcg T3
10 am: 1/4 cynoplus (30 mcg T4 7.5 mcg T3)
Noon: 3.1 mcg T3
3 pm: 3.1 mcg T3
6 pm: 3.1 mcg T3
Bedtime: 1/4 cynoplus

 

[Limon9]

A thread for people to post experiences with various T4:T3 thyroid ratios.

I've taken cynoplus (4:1, 120:30) for over a year without much of an impact on temps, but now that I added cynomel and reduced my cynoplus, I'm seeing increases in temperature. My waking temp is now 97.0F (used to be 96.7), and I'm reaching 98.6F some afternoons.

My current T4:T3 ratio is 2:1, or 60:30mcg. This is just over 1.5 grains, I believe. It's been about one week on this dose, and I plan to increase by 1/2 grain next week, assuming my temps stay below Dr. Barnes' range.

If possible, please share:
-What ratio of t4:t3 works best for you
-What products you use (cynoplus, NDT, tyromix, etc.)
-What other doses you've tried (if any)
-How long you've been taking thyroid

I mostly gave up on the concept of grains (the food and the measurement unit). Dr. Peat mentioned in some interview or other that it was based on the batch-standarized activity of a given dose of Armour, and that it's kind of a legacy measurement when using synthetic products. After trying cynoplus- and T3-only, I began crushing one cynomel and cynoplus together into a fine powder and taking an eighth (weighed on busted jewelery scales) of that with my bedtime snack. It should be 6.9 and 15 micrograms of each hormone. Then I keep a small container of crushed cynomel and take 1-2mcg dabs of powder from it every few hours during the day.

 

[Jessie]

I break the cynoplus up into fourths, and I break the cynomel up into 8ths (3.1 mcg T3 each). Then I spread doses throughout the day.

If I wake up in the middle of the night, I take a little piece of T3 with some milk. During daytime, it looks like this:

7 am: 3.1 mcg T3
10 am: 1/4 cynoplus (30 mcg T4 7.5 mcg T3)
Noon: 3.1 mcg T3
3 pm: 3.1 mcg T3
6 pm: 3.1 mcg T3
Bedtime: 1/4 cynoplus

Interesting. I appreciate your feedback. I'm not on pure T3, but I do split dosages in a similar fashion

I take roughly 1/2 grain 3x a day. It's slightly more actually, considering a 2:1 ratio doesn't perfectly match NDT.

I'm in a good place right now, but I can't get over how literally everything I read about thyroid dosing suggests it be taken all at once, and preferably in the morning.

Peat is really the only outlier to this recommendation. And even though I feel fine right now with split dosages, I think I might try the full dose once a day at some point.

It would really be nice to be able to take one dose, once a day, and not have to worry about it throughout the day.

 

[Limon9]

Peat is really the only outlier to this recommendation. And even though I feel fine right now with split dosages, I think I might try the full dose once a day at some point.

Other ostensible thyroid specialists like Westin Childs also advocate the one-a-day method, stressing the avoidance of calcium. That mineral reduces the absorption of thyroid salts by at most a third, perhaps additively with other malabsorption factors. I mostly ignore it, but you could always try the good ol' 15-grain dosage to overcome a problem.

 

[Jessie]

Other ostensible thyroid specialists like Westin Childs also advocate the one-a-day method, stressing the avoidance of calcium. That mineral reduces the absorption of thyroid salts by at most a third, perhaps additively with other malabsorption factors. I mostly ignore it, but you could always try the good ol' 15-grain dosage to overcome a problem.

Yeah, I don't really care about the calcium thing so much. I'm sure if you took thyroid with a large glass of milk it might inhibit the absorption. But taking it with juice 20-30 minutes before a meal seems to work great for me, even if the proceeding meal is calcium rich.

Besides, most of the negative symptoms from hypothyroidism is from high TSH and high PTH. And calcium is instrumental for the latter.

My only complaint is having to carry a bottle of thyroid on me wherever I go. If I could, I'd rather take one dose and just be done with it.

 

[Limon9]

Besides, most of the negative symptoms from hypothyroidism is from high TSH and high PTH. And calcium is instrumental for the latter.

Big doses of calcium with vitamin D3 are likely to lower PTH for much longer than the "recommended" 4-hour wait, so it's definitely doable, but frequent consumption of calcium is way more consistent if someone is sensitive.

 

[FitnessMike]

This is me on 90mg porcine NDT in the AM with meal that include 500ml of milk, seem kinda perfect? and convertion seem very good for the first time since on high carb diet, although i need to retest rt3 but its expensive pff.

total t4 seem to be running low, could be because of milk blocking t4 absorbtion from NDT?

 

[ecstatichamster]

I'm usually taking 1/2 Cynoplus after each of 3 meals. Sometimes 10mcg or 15mcg of T3 in between.

That equates to 180mcg T4 and 40-45 mcg of T3. Probably more than most people here but that's what my body seems to need.

I switched to NDT for a bit, but didn't thrive on it. I was hypothyroid and everything kind of wound down for me, felt low and flat and cold and bad. It all perked up again with the resumption of T4 and T3.

 

[Jessie]

I'm usually taking 1/2 Cynoplus after each of 3 meals. Sometimes 10mcg or 15mcg of T3 in between.

That equates to 180mcg T4 and 40-45 mcg of T3. Probably more than most people here but that's what my body seems to need.

I switched to NDT for a bit, but didn't thrive on it. I was hypothyroid and everything kind of wound down for me, felt low and flat and cold and bad. It all perked up again with the resumption of T4 and T3.

Interesting. So that T3 in between Cynoplus, is that taken all at once or is it like 2-3mcgs per hour?

 

[ecstatichamster]

Interesting. So that T3 in between Cynoplus, is that taken all at once or is it like 2-3mcgs per hour?

A nibble here and there if I feel I need it.

 

[h.c.]

If possible, please share:
-What ratio of t4:t3 works best for you
-What products you use (cynoplus, NDT, tyromix, etc.)
-What other doses you've tried (if any)
-How long you've been taking thyroid

I never did ratios.
I use two separate products for T3 and T4.
Start with T4, start with 25µg divided in two doses, increase while watching bloodwork, to acceptable level, readjust in required.
If required add T3, if T3 does not increase to acceptable levels. Start low with 2,5 µg - inclease slow while watching bloodwork.
Distribute intake over the day.
Many end up between 150-200 µg T4 and 10-20 µg T3, Basically one one > 20 µg T3. Max 25 µg.
Would never use a combo.
Would never do T3 only! The body needs T4, too.

Here are some rationales (German, use translator): L-Thyroxin & Thybon: Zur verteilten Einnahme der Schilddrüsen-Hormone (Morgens, Mittags, Abends) - H.C.'s Blog


Best,
hans

 

[parallax]

I take 100mcg t4 in the morning and usually about 15-20 mcg t3 spread throughout the day, with the largest dose before bed. I've done 6/1 - 3/1 ratios and honestly I don't notice much of a difference. If my t3 is absent or too low I get more dry eyes and flaky skin, but there seems to be a decent range that is satisfactory with zero undesired effects.

 

[FitnessMike]

Porcine glandular seems to be driving my ft3 high but doesn't raise my t4/ft4, adding 50mg t4 and see how it goes.