What Meds Should I Take To Help With Valley Fever ?

[energyandstruct]

Its a fungal infection

 

[Tristan Loscha]

Clinical Practive Guideline:
https://watermark.silverchair.com/c...KY6bz2qIymQObrRIHx7mWaE14aGnQFjaN8OgDr5xMhsTJ

Wikipedia:
Treatment
Significant disease develops in fewer than 5% of those infected and typically occurs in those with a weakened immune system.[25] Mild asymptomatic cases often do not require any treatment, and the symptoms will go away within a few months. Those with severe symptoms may benefit from anti-fungal therapy, which usually requires 3–6 months of treatment.[26] There is a lack of prospective studies that examine optimal anti-fungal therapy for coccidioidomycosis.

On the whole, oral fluconazole and intravenous amphotericin B are used in progressive or disseminated disease, or in immunocompromised individuals.[25] Amphotericin B used to be the only available treatment,[14] although now there are alternatives, including itraconazole or ketoconazole may be used for milder disease.[27] Fluconazole is the preferred medication for coccidioidal meningitis, due to its penetration into CSF.[3] Intrathecal or intraventricular amphotericin B therapy is used if infection persists after fluconazole treatment.[25] Itraconazole is used for cases that involve treatment of infected person's bones and joints. The antifungal medications posaconazole and voriconazole have also been used to treat coccidioidomycosis. Because the symptoms of valley fever are similar to the common flu and other respiratory diseases, it is important for public health professionals to be aware of the rise of valley fever and the specifics of diagnosis. Greyhound dogs often get valley fever as well, and their treatment regimen involves 6–12 months of ketoconazole, to be taken with food.[28]

Toxicity
Conventional amphotericin B desoxycholate (AmB: used since the 1950s as a primary agent) is known to be associated with increased drug-induced nephrotoxicity (kidney toxicity) impairing kidney function.[29] Other formulations have been developed such as lipid soluble formulations to mitigate such side-effects as direct proximal and distal tubular cytotoxicity. These include liposomal amphotericin B, amphotericin B lipid complex such as Abelcet (brand) amphotericin B phospholipid complex[30] also as AmBisome Intravenous,[31] or Amphotec Intravenous (Generic; Amphotericin B Cholesteryl Sul)[32] and, amphotericin B colloidal dispersion, all shown to exhibit a decrease in nephrotoxicity. The later was not as effective in one study as amphotericin B desoxycholate which had a 50% murine morbidity rate versus zero for the AmB colloidal dispersion.[33]

The cost of AmB deoxycholate, in 2015, for a patient of 70 kilograms (150 lb) at 1 mg/kg/day dosage, was approximately $63.80, compared to 5 mg/kg/day of liposomal AmB at $1318.80, making the less toxic option less accessible.[34]