stargazer1111
Member
- Joined
- Feb 16, 2017
- Messages
- 425
What was the data he used to show Trans Fats caused atherosclerosis? I got interested in Trans Fats a while back, and every study I saw was either observational, or also used an oil that had a much higher level of PUFA than the control. All of the increases in atherosclerosis could have been due to increased PUFA intake. I'm thinking the fact that a lot of places stopped using hydrogenated versions of these high PUFA oils actually made problems much worse, as now there is more PUFA and fewer protective saturated and trans fats in the oils.
Pretty good summary, but you missed one big factor- high body iron stores. Jerome Sullivan even proposed the iron hypothesis back in 1981. Iron stores are elevated in almost every degenerative disease. It also dovetails perfectly with everything you mentioned. Excess iron also promotes PUFA peroxidation. It will also lower vitamin C and E levels in the body. There is research that shows that simply donating blood will increase levels of C, E and other antioxidants in the body.
Good point. Not just iron, but all of the redox active metals are potentially problematic here as they will steal electrons from PUFA creating toxic radical byproducts and then donate those electrons to oxygen creating the superoxide radical. That then creates a chain of events that creates the reactive oxygen and nitrogen species which then kill cells.