What is the pathway of inflammation for sugar?

[Matt Z]

I understand that arachidonic acid is responsible for a lot of inflammation and that can be proved fhrough pathways, but what is sugars pathway to cause inflammation? there has to be at least one if not many.

 

[LLight]

Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats - PubMed

Betaine has been proven effective in treating nonalcoholic fatty liver disease (NAFLD) in animal models, however, its molecular mechanisms remain elusive. The aims of this study were to explore the mechanisms mediating the anti-inflammatory and anti-lipogenic actions of betaine in fructose-fed...

pubmed.ncbi.nlm.nih.gov

Betaine is a byproduct of sugar extraction from beets. Maybe a lack of betaine for people eating large amounts of white sugar, leading to fatty liver, is an explanation.

Note that this study is about fructose overconsumption, not sugar.

 

[somuch4food]

The main argument against sugar and empty carbs in general is that it depletes essential vitamins and deficiencies would probably then cause inflammation.

 

[Matt Z]

I found this old message from Haidut in a thread on the forum here. It's exactly what I was looking for.

"There is no known pathway through which sugar increases inflammation, unlike PUFA for which not only specific pathways exist (e.g. COX/LOX) but it also synergizes with and promoted the synthesis of estrogen, NO, serotonin, prolactin, ACTH, CRH, leptin, etc and all of those have a known role in inflammation. Virtually all of the studies that claim sugar increased inflammation were studies that fed animals/humans BOTH high fat AND high sugar on top of that. Studies with carefully controlled diets that are truly high-sugar (and moderate or low fat) show reductions in weight and inflammation.
Drinking Coke Freely Quadruples Calorie Intake WITHOUT Weight Gain
http://haidut.me/?p=1462"

 

[Funnywhensunny]

I don’t believe sugar, is the problem. Inflammation results from sugar cane sprayed with Monsanto Glysophate.

 

[amd]

[ RP mentioned the first one in a recent interview - the biochemistry path is not always the answer ]

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Defoamer
BUBREAK 4019 is designed for use in batch fermentation systems where alcohol is produced from molasses. BUBREAK 4019 is used as a general purpose foam control agent in the food industry
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[Matt Z]

Interesting angles, thanks for the responses.

 

[mostlylurking]

I understand that arachidonic acid is responsible for a lot of inflammation and that can be proved fhrough pathways, but what is sugars pathway to cause inflammation? there has to be at least one if not many.

Sugar depletes thiamine. If you choose to consume sugar, you need to supplement with thiamine.

If you are deficient in thiamine or if you have a "functional" blockage of thiamine (meaning you can't use what you have because something is blocking it) and you eat some sugar (or have some coffee) the thiamine problem is exacerbated. Without thiamine to act as a cofactor in oxidative metabolism you cannot make ATP and you will be stuck making lactic acid instead. Lactic acid is extremely inflammatory.

I set this to start at the glucose discussion, but the whole video is very good.

View: https://youtu.be/JBJd5G-Zocs?t=596

View: https://www.youtube.com/watch?v=JBJd5G-Zocs

 

[Perry Staltic]

Sugar depletes thiamine

Sugar also competes with vitamin C for absorption, so it in effect can deplete vitamin C which is anti-inflammatory.

 

[Jbird10]

I ran across for the first time yesterday "invert" cane sugar listed on a soda can. Is there any problems with this and is it any different than the sodas listing just cane sugar on the ingredients list?

My thinking on sugar started changing when I ran across James Kreigor's series of sugar articles. I believe he said sugar had no noticeable effect until it reached like 20% total calories then dropped off a cliff on inflammation markers.

 

[mostlylurking]

I ran across for the first time yesterday "invert" cane sugar listed on a soda can. Is there any problems with this and is it any different than the sodas listing just cane sugar on the ingredients list?

My thinking on sugar started changing when I ran across James Kreigor's series of sugar articles. I believe he said sugar had no noticeable effect until it reached like 20% total calories then dropped off a cliff on inflammation markers.

It depends on your thiamine status. Thiamine deficiency is rampant. Many pharmaceutical drugs, including antibiotics block thiamine function and cause thiamine dependency which means you need a whole lot of it to function.

 

[Dobbler]

Depends where you get the sugar from. but i think it's endotoxin. And even then it's not the sugar's fault but the overpopulation of bacteria and sluggish digestion fluids and motility.. so it's not really the sugar.

 

[mostlylurking]

Depends where you get the sugar from. but i think it's endotoxin. And even then it's not the sugar's fault but the overpopulation of bacteria and sluggish digestion fluids and motility.. so it's not really the sugar.

I suspect the problem is more universal than you think. If you are getting sugar from anywhere and you have a thiamine blockage or serious deficiency, almost ANY sugar makes it worse. I put "almost" in there because I don't think that the lactose in my milk made me worse. But I was supplementing with about 200mg thiamine at the time. My thiamine function was blocked by taking Bactrim. My Peaty diet did not work anymore, after 6 years of eating Peaty. link: Bactrim: An Anti-Folate, Anti-Thiamine, Potassium Altering Drug - Hormones Matter

Thiamine deficiency causes a sluggish digestive system, which exacerbates the bacterial overgrowth because things are not moving through and getting digested properly.