What is the minimum salt intake to lull the Renin-Angiotensin-Aldosterone System?

[Such_Umami]

I was wondering if there's an approximate minimum salt or sodium intake that will stop the Renin-Angiotensin-Aldosterone System from kicking in? I'm not interesting in safe numbers that will overshoot the minimum so you don't have to worry about it, I'd like an indication of a good baseline minimum estimate.

edit-obviously there will be co-factors such as activity, sweating etc. I'm just looking for a reasonable estimate.

 

[Such_Umami]

Okay, I've been doing a bit of reading and I have found this chart:

This is the link to the study:

figure 2 | relationship of the 24-h urine sodium excretion (a...

Download scientific diagram | | relationship of the 24-h urine sodium excretion (a reflection of the daily sodium intake) to the ambulatory plasma renin activity (PrA) level and to the 24-h urinary aldosterone excretion values in normal subjects (from Laragh et al. 99 ). because there were only...

www.researchgate.net

Correct me if I'm wrong but It seems that at around 100 mEq/day of urinary excretion, the RAAS is massively cut down. What I really need to figure out is how 100 mEq/day of sodium excretion is equated in sodium intake per day.

Any help?

 

[Such_Umami]

I found a calculator that will turn Meq to miligrams, so based upon the chart above, I can create a ballpark estimation. Here is the calculator:

Conversion Calculator: mEq to Milligrams (mg)

So to significantly lower aldosterone secretion with the minimal sodium intake, you'd need about 2,300 mg of sodium per day. This converts to about 5.75g of salt or about a teaspoon.

 

[youngsinatra]

I found a calculator that will turn Meq to miligrams, so based upon the chart above, I can create a ballpark estimation. Here is the calculator:

Conversion Calculator: mEq to Milligrams (mg)

So to significantly lower aldosterone secretion with the minimal sodium intake, you'd need about 2,300 mg of sodium per day. This converts to about 5.75g of salt or about a teaspoon.

A few months ago I also read about aldosterone and salt intake and I remember that the number 2,300mg per day came up to suppress aldosterone.

I think tho that due to illness or hypothyroidism, one can experience significant sodium loss and thus needs higher salt intakes to suppress aldosterone.

Salt to taste is best probably + plenty amounts of calcium, magnesium and potassium.

 

[Perry Staltic]

Why would anyone want to suppress aldosterone? It's part of an elaborate automatic control system. Leave it alone lest you screw things up.

 

[Such_Umami]

Why would anyone want to suppress aldosterone? It's part of an elaborate automatic control system. Leave it alone lest you screw things up.

When sodium is reduced to a certain level, the renin angiotensin aldosterone system (RAAS) kicks in to boost blood pressure. Aldosterone in this instance isn't beneficial but detrimental on the body. This study will explain it much better.

A quote from the study:

Experimental evidence also indicates that aldosterone, besides being a regulator of extracellular fluid volume and sodium and potassium balance, directly contributes to accelerate renal damage by sustaining cell growth, inflammation, and fibrosis. This occurs through production of growth factors and reactive oxygen species as well as inhibition of extracellular matrix degradation.

Now I agree that too little sodium can be detrimental through the RAAS mechanism. However, I also believe too much sodium can be negative in other ways. So I'm trying to work out what the sweet spot might be.

 

[Such_Umami]

A few months ago I also read about aldosterone and salt intake and I remember that the number 2,300mg per day came up to suppress aldosterone.

I think tho that due to illness or hypothyroidism, one can experience significant sodium loss and thus needs higher salt intakes to suppress aldosterone.

Salt to taste is best probably + plenty amounts of calcium, magnesium and potassium.

That's good because it correlates exactly with my findings above.

 

[Perry Staltic]

When sodium is reduced to a certain level, the renin angiotensin aldosterone system (RAAS) kicks in to boost blood pressure. Aldosterone in this instance isn't beneficial but detrimental on the body. This study will explain it much better.

A quote from the study:

Now I agree that too little sodium can be detrimental through the RAAS mechanism. However, I also believe too much sodium can be negative in other ways. So I'm trying to work out what the sweet spot might be.

Your link doesn't work.

Aldosterone is doing exactly what it's meant to do when it signals the kidneys to retain sodium in order to increase blood pressure.

 

[Perry Staltic]

Sodium doesn't suppress or increase aldosterone. Ang II is the trigger.

 

[WildFreeOrganic]

The RAAS system is always on but I understand your question on how you can reduce it's activities through modulation of sodium intake. Why are you interested in reducing the enzyme production of the RAAS system?

I don't have an answer for your question. I studied the RAAS system but am unsure of specific research that shows how electrolyte intake effects the functions of ACE1 and ACE2.

 

[Perry Staltic]

When sodium is reduced to a certain level, the renin angiotensin aldosterone system (RAAS) kicks in to boost blood pressure. Aldosterone in this instance isn't beneficial but detrimental on the body. This study will explain it much better.

I was able to find thus study by searching for phrases. in your quote The study explores the benefit of aldosterone antagonism for people with chronic kidney disease. Aldosterone antogonism is not meant for healthy people.

 

[Peatness]

Aldosterone and the Risk of Hypertension

Aldosterone, the key hormone in the mineralocorticoid pathway, plays a fundamental role in salt and water homeostasis, blood pressure regulation, and cardiovascular remodeling. Both genomic and non-genomic mechanisms influence aldosterone-induced renal ...

www.ncbi.nlm.nih.gov

 

[Dr. B]

Why would anyone want to suppress aldosterone? It's part of an elaborate automatic control system. Leave it alone lest you screw things up.

Using supplements to suppress woild be risky.
But a food item like salt suppressing it could indicate benefit. Just like milk suppressing prolactin for example. Aldosterone is raised because of lack of salt. Aldosterone has major issues. Its the body trying to hold onto salt

 

[Luann]

I found a calculator that will turn Meq to miligrams, so based upon the chart above, I can create a ballpark estimation. Here is the calculator:

Conversion Calculator: mEq to Milligrams (mg)

So to significantly lower aldosterone secretion with the minimal sodium intake, you'd need about 2,300 mg of sodium per day. This converts to about 5.75g of salt or about a teaspoon.

This was helpful, thanks.

 

[EnergeticLeo]

Salt, energy, metabolic rate, and longevity

Despite numerous publications showing that diuretics could cause the edematous problems that they were supposed to remedy, they have been one of the most profitable types of drug. Dietary salt restriction has become a cultural cliche, largely as a consequence of the belief that sodium...

raypeat.com

Salt deficiency lowers blood volume, because water follows salt, and so the RAAS system kicks in to increase blood pressure. The problem is that this 'regulated' / 'compensated' state is inflammatory compared to the optimal state with adequate sodium intake. Just like cortisol elevation is a regulatory mechanism that can help one survive in the short term but is far from the optimal state.

 

[EnergeticLeo]

I was wondering if there's an approximate minimum salt or sodium intake that will stop the Renin-Angiotensin-Aldosterone System from kicking in? I'm not interesting in safe numbers that will overshoot the minimum so you don't have to worry about it, I'd like an indication of a good baseline minimum estimate.

edit-obviously there will be co-factors such as activity, sweating etc. I'm just looking for a reasonable estimate.

haidut here says that some human studies suggest less than 5000 mg elemental sodium / day chronically activates the RAA system:

View: https://youtu.be/s2hicm_Uo3E?t=2889

 

[EnergeticLeo]

I believe this is the study he is referring to

Low Sodium Diet Increases CVD / Death Regardless Of Person's Blood Pressure

Another big point in favor of salt and this time the scientists actually provide salient explanation for why the low salt diet was detrimental - i.e. it increases renin, aldosterone and adrenaline. Pretty much what Peat wrote...about 30 years before this study. It also matches well another study...

raypeatforum.com

 

[Ras]

If low sodium diets are so harmful, why are the Yonomami so healthy?

 

[EnergeticLeo]

If low sodium diets are so harmful, why are the Yonomami so healthy?

Low sodium diets are only harmful when the metabolic rate is low. When the metabolic rate is optimal, sodium retention is much better.

 

[Dr. B]

Low sodium diets are only harmful when the metabolic rate is low. When the metabolic rate is optimal, sodium retention is much better.

Shouldnt a low metabolism cause craving for salt then? Yet salt becomes difficult t consume for low metabolic people. Also how are people eating al this salt? You cant put much on meat and rice. It makes milk taste horrible. The only thing you can really put a good amount salt in is orange juice or coconut water.