What Is The Best Form Of Magnesium To Take?

[Nebula]

What are the excellents results? What metrics are you monitoring? Or what were you feeling that you consider an improvement? For example, higher energy levels?

High calcium antagonism. Teeth felt like they were constantly being coated with calcium phosphate ions. Ph of mouth/gums felt perfect. Everything I associate with optimal metabolism. Deep sleep. Great digestion. Increased dopamine. Lots of heat generation after meals.

I definitely agree high amounts of magnesium chloride under poor energetic conditions does nothing positive or can have acidic effects, cause blood pressure issues as it pushes out sodium. That doesn’t happen when thyroid/atp is working, but any high amounts of magnesium supplementation will probably have similar negative effects when it’s not entering cells and just floating around in the blood.

 

[Frankdee20]

I use Triple Mag by Vital Nutrients and it’s my favorite (Oxide, Malate, and Glycinate 10percent) .... Only one capsule provides 250 mg

 

[Amazoniac]

I was trying to find early november's 'This Time for Real: The Best Magnesium Form Ever' thread, but came across the current one and seems an appropriate place to post this:
- The Coordination Chemistry of Bio-Relevant Ligands and Their Magnesium Complexes

 

[koky]

response from on mag chloride:

I can confirm that all raw materials for our products are tested at source for heavy metals and are in compliance with UK and all international limits. Unfortunately, we are unable to share documentation of this nature with our customers.

Best Regards,
Simon


Simon Burton
Quality Manager

WHY NOT?

 

[Amazoniac]

- Synthesis and Chemical and Biological Evaluation of a Glycine Tripeptide Chelate of Magnesium

Spoiler

"Typical magnesium supplements include magnesium oxide, magnesium chloride, magnesium sulfate, and other organic magnesium formulations (see Table 1). Aqueous solubilities of such supplements vary greatly, from poorly soluble magnesium oxide to more soluble magnesium salts (Table 1)."

"There is a corollary between the solubility of magnesium compounds and their subsequent bioavailability—the more soluble the supplement, typically, the greater the bioavailability [34,35,36]. As such, although magnesium oxide is commonly used as a magnesium supplement for its ~60% magnesium composition, it lacks substantial water solubility and exhibits lower bioavailability than other organic magnesium salts [34,36]. While the chloride and sulfate magnesium salts exhibit substantial water solubility, they rapidly dissociate and leave available reactive sites on the Mg2+ site, making it more susceptible to precipitating from bioagents, such as phytates, and hydration—thus resulting in laxation [3,37,38,39]. As such, biologically relevant chelate ligands are utilized to occupy reactive sites on the magnesium to reduce laxation and increase solubility, subsequently resulting in greater bioavailability. This bioavailability is highly significant, as it will determine magnesium uptake within the body, and is largely dependent on a relatively acidic pH, as magnesium is taken up unequally throughout the length of the small intestine [37,38,40]."

"The naturally occurring glycine peptide trimer, triglycine (IUPAC: 2-[[2-[(2aminoacetyl)amino]acetyl]amino]acetic acid—HG3: not to be confused with trisglycine, three individual glycine monomers bound to a metal ion) [41], isolated from the Ackee (Blighia sapida) seed in 1968 by Fowden et al. [42], was chosen as the magnesium chelate ligand by virtue of several significant characteristics, namely, multiple Lewis base moieties that give rise to entropically favored binding (bidentate, tridentate, or tetradentate), extensive hydrogen bond donors/acceptors—when both free and complexed—offering inherent stability [43], well-understood coordination chemistry through the carboxylic acid moiety [44], weakly acidic character [37]; and evidence indicating a higher achievable plasma concentration than both its monomer and dimer progenitors [45]."

"Solubility studies show that the MgG3 complex shows substantially increased water solubility at pH = 7 (169 ± 12.5 g/100 mL) relative to both magnesium salts and other current magnesium nutraceuticals." "This solubility of MgG3 is approximately 3× greater than that of magnesium chloride, 5× more soluble than magnesium sulfate, and 8× more soluble than magnesium citrate—more commonly used magnesium supplementation formulations. Solutions of MgG3 turn a yellow color upon solution saturation. Given previous studies, this increased solubility is believed to be to contribute significantly to the bioavailability of the MgG3 complex."

"Cellular uptake data was collected at incubation times of 1 h (required kit incubation time), 4 h (the amount of time required for uptake in the GI), and 24 h (the amount of time required for a complex to clear the GI). It was hypothesized that the exceptional solubility of MgG3 (determined to be 169 ± 12.5 g/100 mL over triplicate independent runs), that stems from the coordination of the triamino acid HG3, would result in increased bioavailability and a subsequent increase in cellular uptake. Cellular uptake data indicate that MgG3 exhibits greater cellular uptake than MgBG and MgCl2 at a significantly lower percent composition of magnesium (9, 14 and 25%, respectively) and that uptake maintains linearity (Figures S16 and S18)—uptake relative to %Mg composition is shown in Supplemental Data (Figure S17). This greater level of uptake was observed at both 1 and 4 h. At 24 h, data indicated that cell saturation had occurred (Figure 7)."

"Kinetic evaluation of cellular uptake was also conducted to determine how uptake of MgG3 compared to that of MgBG and MgCl2. Kinetics were evaluated utilizing the slope of the line of uptake of the complex in the CaCo-2 cells. Kinetics of uptake were evaluated at 1 and 4 h—kinetics evaluation at 24 h was not pertinent, due to the observable saturation of the cells indicated by the plateau of the uptake curve at magnesium concentrations greater than 10 nmols. At 1 h, MgG3 exhibited uptake approximately 1.6× faster than MgCl2, and approximately 1.9× faster than that of MgBG. At 4 h, MgG3 showed uptake that was approximately 1.4× faster than that of MgCl2, and approximately 1.5× faster than that of MgBG (Figure S16). It should also be noted that at 4 h, MgG3 uptake had plateaued (at 30 nmols), while both MgCl2 and MgBG had not. This suggests that MgG3 achieves cellular uptake faster than both MgCl2 and MgBG."