Ray Peat said:Niacinamide inhibits the release of free fatty acids from the tissues, and thyroid sustains the oxidation of glucose.
Ray Peat said:Niacinamide inhibits nitric oxide synthesis (Fukuzawa, et al., 1997; Fujimura, et al., 1997) and protects against some of its toxic effects (Narang and Krishna, 2005). Women are more likely than men to be deficient in niacin, and are twice as likely to develop pellagra from a niacin deficiency. This is because estrogen shifts tryptophan metabolism toward the formation of serotonin, and away from synthesizing niacin. Niacin has many other effects that would be beneficial in multiple sclerosis, for example inhibiting the release of free fatty acids from tissues.
Ray Peat said:Niacinamide protects mitochondrial respiration from many of the age-related factors that can damage mitochondria and decrease energy production. Lipopolysaccharide, the bacterial endotoxin, increases the production of the free radical nitric oxide, leading to the secretion of inflammatory mediators and the suppression of energy production by the mitochondria. These effects are blocked by niacinamide (Fukuzawa, et al., 1997). Calorie restriction also protects mitochondrial respiration, in yeasts (Lin, et al., 2002) and rats (Broderick, et al., 2002)
Ray Peat said:Niacinamide can have an “antiinflammatory” function, preventing death from multiple organ failure, by interupting the reactions to nitric oxide and peroxynitrile (Cuzzocrea, et al., 1999).
Ray Peat said:Niacinamide, used in moderate doses, can safely help to restrain the excessive production of free fatty acids, and also helps to limit the wasteful conversion of glucose into fat. There is evidence that diabetics are chronically deficient in niacin. Excess fatty acids in the blood probably divert tryptophan from niacin synthesis into serotonin synthesis.
Ray Peat said:Niacinamide is a nutrient that inhibits the release of fatty acids, and it also activates phagocytic activity and lowers phosphate. It protects against the development of scars in spinal cord injuries, facilitates recovery from traumatic brain injury, and accelerates healing generally. While it generally supports immunity, it’s protective against autoimmunity. It can cause tumor cells to either mature or disintegrate, but it prolongs the replicative life of cultured cells, and protects against excitotoxicity.
The amounts needed seem large if niacinamide is thought of as “vitamin B3,” but it should be considered as a factor that compensates for our unphysiological exposure to inappropriate fats. Aspirin and vitamin E are other natural substances that are therapeutic in “unnaturally” large amounts because of our continual exposure to the highly unsaturated plant-derived n-3 and n-6 fats.
Ray Peat said:Suppressing fatty acid oxidation improves the contraction of the heart muscle and increases the efficiency of oxygen use (Chandler, et al., 2003). Various drugs are being considered for that purpose, but niacinamide is already being used to improve heart function, since it lowers the concentration of free fatty acids.
Ray Peat said:Niacinamide, by lowering free fatty acids and regulating the redox system, supporting sugar oxidation, is useful in the whole spectrum of metabolic degenerative diseases.
|P||Niacinimide As A Benzo||Ask For Help or Advice||7|
|A note on high dose niacinimide||B3/Niacinamide||3|
|Why an antidepressant (SSRI) could be used to treat COVID-19||Miscellaneous Health Discussions||13|
|Ray used thyroid to slow his metabolism down. Everyone else doing the opposite.||Danny Roddy||26|
|F||anyone used hydrocortisone to help tolerate/utilize thyroid?||Ask For Help or Advice||23|
|Microsoft Cloud Is Being Used By France For COVID Data||Articles & Scientific Studies||0|
|I Used Shockwave Therapy On My Penis For Stronger Erections||Experiments||12|
|I Realized I'm Basically Always In Pain, And I've Just Gotten Used To It. Aspirin And Yoga Fixes It||Metabolism||25|
|What Can Be Used To Lower Histamine But Not Cortisol||Fruit Juice||51|
|P||Has Anyone Used Flonorm From Mexico For Sibo?||Supplements, Pharmaceutical Drugs||0|
|J||Does Your Gut Get Used To Milk?||Working Through Milk Issues||20|
|Coronavirus Breakthrough As Scientists Discover A Drug Used To Treat HEAD LICE Can Kill COVID-19 Cel||Viruses, Parasites, Fungus, Vaccines||48|
|Searching For A Health Website I Used To Frequent||Health||5|
|How Much Soy Lecithin Is Commonly Used In Chocolate?||Sweets, Snacks||13|
|Males That Have Used Progesterone For Sleep With Success (Poll)||Polls||52|
|Has Anyone Here Used Fasoracetam?||Pharmaceutical Drugs||5|
|T||Can Coq10/Ubiquinol Be Used Topically?||Ask For Help or Advice||1|
|F||Has Anyone Had Used Legitimate DHT In The Past? And Can Report How It Made Them Feel?||Thyroid and Hormones||8|
|New Gene-Edited Cooking Oil Is Secretly Being Used In Restaurants||Breaking News||4|
|T||Ketanserin Successfully Used In Schizophrenia Patient For Hallucinations||Scientific Studies||3|
|A||Has Anyone Used DNA Analyzer Services For Nutritional Info? Useful?||Health||0|
|C||Anyone Used A "coach" To Help With Women's Issues, Metabolism, And Thyroid?||Female Issues||3|
|L||Can Well Cooked Mushrooms Be Used Every Day Instead Of Raw Carrot Salad?||Digestion, Gut Flora||2|
|L||What Kind Of Vinegar Should Be Used For The Carrot Salad?||Recipes||6|
|G||How Is Lactose Used By The Body Compare To Other Sugars?||Metabolism||1|
|M||Vitamins And Their Used By Date||Supplements, Pharmaceutical Drugs||1|
|W||Where To Sell Used Lab Equipment Online?||The Ray Peat Forum Lounge||2|
|High Norepinephrine Can Be Used To Diagnose Fibromyalgia||Scientific Studies||18|
|R||Is There A NDT Dose That Can Be Used Indefinitely?||Supplements, Pharmaceutical Drugs||20|
|A||Gelatin Needs To Be Used As Religiously As Sugar||Ask For Help or Advice||128|
|Massive Fraud Was Used To Sell The Public On The Safety Of HRT (estrogen)||Scientific Studies||16|
|Chemicals Used In Packaging, Carpets And Utensils (Telfon) Are Endocrine Disruptors||Scientific Studies||25|
|Another Human Study Shows Methylene Blue (MB) May Treat Alzheimer Disease (AD) If Used On Its Own||Scientific Studies||25|
|R||Has Anyone Used Pramipexole?||Pharmaceutical Drugs||16|
|L||Peat Used To Be A Fan Of Low Carb, No Sugar Diets||Ray Peat Quotes||38|
|Insults, And Focus On People, Rather Than People's Ideas, Is Used To Control You||Society||2|
|Has Anyone Used "Restore" For Gut Health||Digestion||9|
|M||Has Anyone Used Progesterone To Lower Serotonin Levels In The Brain?||Progesterone||51|
|Activated Charcoal Should Be Used With Caution||Activated Charcoal||37|
|U||Has Anyone Used Farmacias Del Nino?||Suppliers||54|
|D||Cortisol Lowers Estrogen - Cortisol Used To Treat Cancer, Autoimmunity, And More||Ask For Help or Advice||24|
|Neanderthals Used Salicylic Acid And Antibiotics More Than 50,000 Years Ago||Scientific Studies||6|
|Tilapia Skin Used For Bandage On Burn Patients||Experiments||3|
|Examine.com - Awesome Site To View Supplements Used On Humans||Ask For Help or Advice||3|
|Has Anyone Used Activated Vitamin B-1, Diphosphate ?||Supplements||1|
|T||Dr. Emanuel Revici Used Fatty Acids To Kill Cancer||Cancer||29|
|K||Has Anyone Used Vitamin K2 On Their Dogs?||Animals||17|
|Body Temperature At 35.8○C (96.44 F○C) Since IF - Used To Be 37.5○C (99.5○F)||Ask For Help or Advice||67|
|D||Who Has Used Or Is Using DHT?||Ask For Help or Advice||356|
|"Natural Aspirin" Used Prehistorically||Aspirin||10|