What Increases Or Decreases CRH?

[Flo93]

Increase:
• Fear
• Stress
• Pain
• Hypoglycemia
• Activation of kappa opioid receptors
• Blocking mu opioid receptors
• Activation of 5-HT2C receptors
• BDNF (activation of TrkB receptors)
• Interleukin 1
• Interleukin 6
• TNF-a
• LPS
• Acetylcholine

Decrease:
• Opiates
• Benzodiazepines
• Cortisol
• Hyperglycemia

Further ideas?

 

[Andman]

pregnenolone :)

 

[Flo93]

Decrease:
• Caffeine (New effects of caffeine on corticotropin-releasing hormone (CRH)-induced stress along the intrafollicular classical hypothalamic-pituitary-adrenal (HPA) axis (CRH-R1/2, IP 3 -R, ACTH, MC-R2) and the neurogenic non-HPA axis (substance P, p75 NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles - PubMed)