IVILA
Member
- Joined
- Dec 1, 2020
- Messages
- 192
Why would estrone be at a high end of the reference range whereas estradiol be at the low end while prolactin is low? Is it due to aromatase conversion or what?
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"Estrone may be a weak estrogen but it is the main estrogen produced peripherally by both men and women (mostly in fat tissue). Its synthesis grows with age due to the high expression in aromatase in fat tissue, and it is the main "reservoir" of estrogen in the organism as it can easily be converted to estradiol and estriol as needed.Why would estrone be at a high end of the reference range whereas estradiol be at the low end while prolactin is low? Is it due to aromatase conversion or what?
It's usually from the stress-induced rise in ACTH -> high DHEA-S output -> peripheral DHEA aromatization -> estrone.
Serum estradiol is mainly an indicator of intratesticualr testosterone production, so it's not surprising it's low in the case of elevated estrone, which along with prolactin is a better indicator of systemic estrogen load.
I don't think so. Since estrone is formed from the conversion of androstenedione, I have read that people who have a high level of estrone but a low level of estradiol have a genetic issue with the enzymes so their body prefers the left side of the conversion of DHEA into androstenedione followed by estrone. This may also mean that their testosterone may be lower than optimal in this case since the DHEA is not converting to testosterone. Not sure what can fix this as some say that the use of 7-keto-DHEA would help with this.High estrone means high aromatase activity converting testosterone into estrone. Estradiol is produced by men in the testis but apparently can be converted from estrone too. Where and how would be interesting to know.
I recently got tested too. Both dhea and androstenedione was on the lower end but T was high. I think it’s either a sulfation problem, or low dhea/adrenal function in general or both. That’s why estrone might be high because it isn’t getting sulfated. I never tested E1-S so I’m not so sure but it’s a guess.Bump, got some lab results back with estradiol on the low end, but estrone above range for men. Did you ever try 7-keto-dhea? I think you could be right about the dhea levels and converting to test as my test was on the lower side, but dhea-s near upper level, dhea a bit above middle, Pregnenolone near middle or above. Any recommendations for lowering the estrone would be appreciated. Forgot to add also had prolactin which was around 13 (Ray thought levels should be around 9-12).