Zinc, Magnesium, Selenium and Depression: A Review of the Evidence, Potential Mechanisms and Implications
Dietary zinc deficiency alters 5 alpha-reduction and aromatization of testosterone and androgen and estrogen receptors in rat liver. - PubMed - NCBIshowed a significantly higher level of estrogen receptor in zinc-deficient rats (36.6 +/- 3.4 fmol/mg protein) than in pair-fed controls (23.3 +/- 2.2 fmol/mg protein) and a significantly lower level of androgen binding sites in rats fed the zinc-deficient diet (6.7 +/- 0.7 fmol/mg protein) than in pair-fed control rats (11.3 +/- 1.2 fmol/mg protein).
How ?the problem is,you can't actually take Zinc everyday.
since it can oxidize vitamins.
I've read on other thread that 'RP said supplemental zinc could oxidize vitamins in the intestine.'
'For that reason, according to him, no more than 10mg of zinc ( either sulfate or gluconate) should be used and for a period of 10 days max.'
Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. - PubMed - NCBIAt the end of four weeks hair, urine and erythrocyte zinc levels rose significantly (p less than 0.005, p less than 0.001, and p less than 0.001) during zinc picolinate administration. There was no significant change in any of these parameters from zinc gluconate, zinc citrate or placebo administration.
Outstanding knowledge. Thanks.Aromatase, Endotoxins, Cortisol and the inflammatory cytokine IL-6 promote Estrogen synthesis. Zinc has inhibiting effects on all of them. Zinc also antagonizes Copper (preventing excess) and Copper is estrogenic. It also competes with Cadmium, prevents testicular damage from Lead and Aluminium, and these 3 metals are classified as metalloestrogens with known estrogenic effects. Zinc is low in prostate cancer which Estrogen promotes, and bald men have significantly higher risks of aggressive prostate cancer.
The recommended form advice is weird to begin with, since forms other than Picolinate have been shown to be completely ineffective at affecting Zinc levels.
Comparative absorption of zinc picolinate, zinc citrate and zinc gluconate in humans. - PubMed - NCBI
Effect of iron, vitamin B-6 and picolinic acid on zinc absorption in the rat. - PubMed - NCBI
It also requires more than 50mg of Picolinate to have an effect on serum levels, although this is trumped by average diets that include phytic acid and gut irritants that cause intestinal permeability, reducing absorption of minerals. Zinc itself shows efficacy in restoring intestinal barrier integrity, and deficiency causes intestinal permeability.
Perhaps one should take it several hours away from meals to avoid the oxidation he mentions (can't find it happening in studies though), but 10mg is definitely not enough when it comes to protection against hair loss and regrowth. Personally I have almost always taken it away from meals with a sip of Apple Cider Vinegar, usually when I woke up and did IF; mainly because the isolated effect seemed more potent than with meals. It acted like a nootropic to go to class/work when I had more social anxiety, completely eliminated stress.
Up to 100mg. Absorbtion rate decreases as dose increases, and decreased minerals absorption from intestinal permeability is often present in mpb. 100mg can be fine for the first weeks to resplenish. P-5-P (50mg) will also help increase absorption.Hey man, as part of your protocol then, I have to take 50mg of Zinc Picolinate instead of the standard 25?
Up to 100mg. Absorbtion rate decreases as dose increases, and decreased minerals absorption from intestinal permeability is often present in mpb. 100mg can be fine for the first weeks to resplenish. P-5-P (50mg) will also help increase absorption.
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